One of the biggest challenges in regenerative medicine is promoting sufficient vascularisation of tissue-engineered constructs. One approach to overcome this challenge is to target the cellular hypoxia inducible factor (HIF-1α) pathway, which responds to low oxygen concentration (hypoxia) and results in the activation of numerous pro-angiogenic genes including vascular endothelial growth factor...

This review focuses on the therapeutic effects of ions when released in physiological environments. Recent studies have shown that metallic like Ag+, Sr2+, Mg2+, Mn2+, Cu2+, Ca2+, P+5, etc., promising results drug delivery systems and regenerative medicine. These can be loaded nanoparticles, mesoporous bioactive glass nanoparticles (MBGNs), hydroxyapatite (HA), calcium phosphates, polymeric coa...

materials used in the body, especially the materials used in various oral cavity regions should be stable and passive without any interactions with the body tissues or fluids. dental amalgam, c omposite resins and dental cements are the materials of choice with such properties. the first attempts to produce active materials, which could interact with the human body tissues and fluids were promp...

the cytotoxicity of the biomaterials is a key issue that should be addressed prior to pre-clinical applications. this study was designed to evaluate and compare the cytotoxixity of two forms of bioactive glasses:nanopowder:andmicropowder. human hgf1-pi53 gingival fibroblast cells were used to evaluate the cytotoxicity of 0.5, 1, 1.5, 2, 5, 10, 15 and 20 mg/ml concentrations of the two bioactive...

Bioactive glasses are known to stimulate bone healing, and the incorporation of strontium has the potential to increase their potency. In this study, calcium oxide in the 45S5 bioactive glass composition was partially (50%, Sr50) or fully (100%, Sr100) substituted with strontium oxide on a molar basis. The effects of the substitution on bioactive glass properties were studied, including density...