A microfabrication approach to produce a microelectrode array that is suitable for use with human patients has been developed. The device is comprised of materials that are consistent with those of clinically used macroelectrodes (platinum electrode contacts suspended within a biomedical grade polydimethylsiloxane, PDMS). Photolithography, metal deposition, wire bonding, and PDMS encapsulation ...

The present work describes the first example of a wearable salivary metabolite biosensor based on the integration of a printable enzymatic electrode on a mouthguard. The new mouthguard enzymatic biosensor, based on an immobilized lactate oxidase and a low potential detection of the peroxide product, exhibits high sensitivity, selectivity and stability using whole human saliva samples. Such non-...

In the present study, ion adsorption on the outer and inner surfaces of single-walled carbon nanotubes (SWCNTs) in different aqueous and organic electrolytes was analysed. It was found that the fundamental properties of tube size and electronic structure, particularly the transition between van Hove singularities (the band gap), reflected by the shape of the cyclic voltammogram and increase in ...

A facile technique was demonstrated for the controlled assembly and alignment of multi-segment nanowires using bioengineered polypeptides. An elastin-like-polypeptide (ELP)-based biopolymer consisting of a hexahistine cluster at each end (His(6)-ELP-His(6)) was generated and purified by taking advantage of the reversible phase transition property of ELP. The affinity between the His(6) domain o...

Malfunctioning sensory systems can severely impact quality of life and repair is not always possible. One solution, called sensory substitution, is to use another sensory system to bring lost information to the brain. This approach often involves the use of bioengineered devices that electrically stimulate somatosensory fibers. Interestingly, the tongue is an ideal location for electrotactile s...

From the bench-mark work on microfluidics from the Whitesides's group in 2007, paper technology has experienced significant growth, particularly regarding applications in biomedical research and clinical diagnostics. Besides the structural properties supporting microfluidics, other advantageous features of paper materials, including their versatility, disposability and low cost, show off the gr...

McGowan Institute of Regenerative Medicine, 450 Technology Drive, Suite 300, Pittsburgh, PA 15219 Saurav Basu, Department of Biomedical Engineering, 5000 Forbes Avenue, HH120, Pittsburgh, PA 15213 Gustavo K. Rohde, and Department of Biomedical Engineering, 5000 Forbes Avenue, HH120, Pittsburgh, PA 15213 Christopher J. Bettinger Department of Biomedical Engineering, Department of Materials Scien...

Ionic polymer-metal composites (IPMCs) have recently received tremendous interest as soft biomimetic actuators and sensors in various bioengineering and human affinity applications, such as artificial muscles and actuators, aquatic propulsors, robotic end-effectors, and active catheters. Main challenges in developing biomimetic actuators are the attainment of high strain and actuation force at ...

Ferroelectric polarization switching of high aspect ratio (>80:1) PbZr(0.52)Ti(0.48)O(3) (PZT) microtubes with a wall thickness of ~200 nm was investigated. A charge-based technique was used to assess the dielectric and ferroelectric properties of individual mechanically-unconstrained PZT microtubes with interdigitated electrodes. An enhancement in the degree of ferroelastic (non-180 degrees ) ...

In electron beam ion sources, step-wise ionization to high charge states is accomplished by magnetically confined electron beam. Electron space charge and high voltage electrodes confine the ions. The relativistic heavy ion collider (RHIC) ion source Debye length meets requirements for instabilities with free source of energy to grow. Electrons stripped from ions provide energy for a variety of...