In the last few decades, the development of miniature biological sensors that can detect and measure different phenomena at the nanoscale has led to transformative disease diagnosis and treatment techniques. Among others, biofunctional Raman nanoparticles have been utilized in vitro and in vivo for multiplexed diagnosis and detection of different biological agents. However, existing solutions r...

With a rapid improvement of smartphone hardware and software, especially complementary metal oxide semiconductor (CMOS) cameras, many optical biosensors based on smartphone platforms have been presented, which have pushed the development of the point-of-care testing (POCT). Imaging-based and spectrometry-based detection techniques have been widely explored via different approaches. Combined wit...

This paper presents a review of micro- and nano-structure based oligonucleotide detection and quantification techniques. The characteristics of such devices make them very attractive for Point-of-Care or On-Site-Testing biosensing applications. Their small scale means that they can be robust and portable, their compatibility with modern CMOS electronics means that they can easily be incorporate...

Diffractometric biosensing is a promising technology to overcome critical limitations of refractometric biosensors, the dominant class label-free optical transducers. These manifest themselves by higher noise and drifts due insufficient rejection refractive index fluctuations caused variation in temperature, solvent concentration, most prominently, non-specific binding. biosensors these with in...

CMOS Contact Imagers for Spectrally-Multiplexed Fluorescence DNA Biosensing Derek Ho Doctor of Philosophy Graduate Department of Electrical and Computer Engineering University of Toronto 2013 Within the realm of biosensing, DNA analysis has become an indispensable research tool in medicine, enabling the investigation of relationships among genes, proteins, and drugs. Conventional DNA microarray...

The separate fields of conducting polymer-based electrochemical sensors and virus-based molecular recognition offer numerous advantages for biosensing. Grafting M13 bacteriophage into an array of poly (3,4-ethylenedioxythiophene) (PEDOT) nanowires generated hybrids of conducting polymers and viruses. The virus incorporation into the polymeric backbone of PEDOT occurs during electropolymerizatio...

Graphene's unique properties have made it a popular candidate for nanomaterial based biosensors. Its remarkable characteristics have led to its rapid development in the electrochemical biosensing, field effect transistors, and optical biosensing as well as the creation graphene-metal nanoparticle hybrids for improved performance. This article comprehensively reviews the most recent trends in gr...

Because of their photo-optical distinctiveness and biocompatibility, gold nanoparticles (AuNPs) have proven to be powerful tools in various nanomedicinal and nanomedical applications. In this review article, we discuss recent advances in the application of AuNPs in diagnostic imaging, biosensing and binary cancer therapeutic techniques. We also provide an eclectic collection of AuNPs delivery s...