Concerns have recently been raised about a possible link between suicidal ideation and the use of SSRIs in teenagers diagnosed with unipolar depression, such that the USA FDA and UK CSM have issued warnings regarding the use of SSRIs in adolescents with depression. We investigated this phenomenon first by recognizing that the initial presentation of unipolar and bipolar depression may only diff...

objective: with regard to the abundance of mood disorders among the artists and, life and death of hedayat, number and time of creation of his works, this hypothesis that hedayat suffered from a bipolar mood disorder (type ii, or bipolar spectrum) is studied in the descriptive psychiatry framework. methods: his biographies, medical records, letters exchanged between him and his friends and rela...

BACKGROUND Studies have shown that chronic inflammation may play a vital role in the pathophysiology of both gastroesophageal reflux disease (GERD) and bipolar disorder. Among patients with GERD, the risk of bipolar disorder has not been well characterized. OBJECTIVE We explored the relationship between GERD and the subsequent development of bipolar disorder, and examined the risk factors for...

OBJECTIVE Self-mutilation has traditionally been associated with borderline personality disorder, and seldom examined separately from suicide attempts. Clinical experience suggests that self-mutilation is common in bipolar disorder. METHODS A family study was conducted on the molecular genetics of depression and personality, in which the proband had been treated for depression. All probands a...

OBJECTIVE Evidence that clinical treatment reduces suicide risk in major depressive disorder (MDD) is limited and inconsistent. Since lithium shows major antisuicidal effects in bipolar disorders and in heterogeneous mood disorder samples, we evaluated evidence of antisuicidal effects of lithium in patients with recurrent MDD. DATA SOURCES We searched MEDLINE (January 1966 to April 2006; sear...

OBJECTIVE Bipolar disorder is strongly associated with suicidal ideations, attempts and commissions. Although several studies have been conducted on suicide risk factors in patients with bipolar disorder worldwide, a comprehensive study has not been reported from Iran. METHODS Patients with bipolar disorder type I, hospitalized in Iran Hospital of Psychiatry since May 2008 to August 2011 were...

This section of Focus on Child and Adolescent Mental Health presents 3 longitudinal follow-up studies of suicide attempts in youth with first-episode psychosis, sleep problems among adolescents following a disastrous earthquake, and course of mood symptoms (irritability vs elation) in youth with bipolar disorder, as well as a double-blind, placebo-controlled trial that evaluated the efficacy an...

This study examined the relationship between the overall rate of psychiatric disorders and suicides in the nation's largest state prison population. Data from 234,031 Texas Department of Criminal Justice inmates who were incarcerated for any duration between September 2006 and September 2007 were analyzed by Poisson regression, to assess the independent associations of major psychiatric disorde...

767 J Clin Psychiatry 68:5, May 2007 he future of child and adolescent psychiatry lies in the identification of prodromal presentations and risk factors associated with the onset and progression of psychopathology. Only once we begin to understand the early clinical manifestations of psychiatric disorders and the risk factors, genetic and environmental, associated with illness onset and outcome...

BACKGROUND/AIMS The substitution of valine by methionine in the brain-derived neurotrophic factor (BDNF Val/Met) gene alters the intracellular trafficking and regulated secretion of BDNF. This study tested whether the BDNF Val/Met polymorphism is associated with bipolar disorder in Korean subjects, and whether clinical features vary according to genotype. METHODS The allelic and genotypic dis...