نتایج جستجو برای: birc5

تعداد نتایج: 294  

2017
Marieke A. de Graaff Shruti Malu Irma Guardiola Alwine B. Kruisselbrink Yvonne de Jong Willem E. Corver H. Gelderblom Patrick Hwu Torsten O. Nielsen Alexander J. Lazar Neeta Somaiah Judith V.M.G. Bovée

Myxoid liposarcoma (MLS) is a soft tissue sarcoma characterized by a recurrent t(12;16) translocation. Although tumors are initially radio- and chemosensitive, the management of inoperable or metastatic MLS can be challenging. Therefore, our aim was to identify novel targets for systemic therapy. We performed an in vitro high-throughput drug screen using three MLS cell lines (402091, 1765092, D...

2017
Donghui Zhang Enqin Liu Jian Kang Xin Yang Hong Liu

Hepatocellular carcinoma (HCC) is one of the most common types of malignant tumors with poor sensitivity to chemotherapy drugs and poor prognosis among patients. In the present study, we downloaded the original data from the Gene Expression Omnibus and compared gene expression profiles of liver cancer cells in patients with HCC with those of colon epithelial cells of healthy controls to identif...

Journal: :Fundamental Toxicological Sciences 2023

Cadmium (Cd) is an environmental pollutant with toxic effects in various tissues, including the kidney. In our previous study, Cd changed expression of baculoviral inhibitor apoptosis protein repeat-containing (BIRC) family genes human proximal tubular cells. BIRC inhibit apoptosis, and inducing pathway approach for anticancer therapeutics. this effect on was examined HeLa cervical cancer treat...

Journal: :Carcinogenesis 2014
Nora I Hipp Lisa Christner Thomas Wirth Wolfgang Mueller-Klieser Stefan Walenta Evelin Schröck Klaus-Michael Debatin Christian Beltinger

The oncogenes MYCN and survivin (BIRC5) maintain aggressiveness of diverse cancers including sarcomas. To investigate whether these oncogenes cooperate in initial malignant transformation, we transduced them into Rat-1 fibroblasts. Indeed, survivin enhanced MYCN-driven contact-uninhibited and anchorage-independent growth in vitro. Importantly, upon subcutaneous transplantation into mice, cells ...

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