Antidepressant-sensitive serotonin (5-hydroxytryptamine, 5HT) transporters (SERTs) are responsible for efficient synaptic clearance of extracellular 5HT. Previously (Qian, Y., Galli, A., Ramamoorthy, S., Risso, S., DeFelice, L. J., and Blakely, R. D. (1997) J. Neurosci. 17, 45-47), we demonstrated that protein kinase (PKC)-linked pathways in transfected HEK-293 cells lead to the internalization...

Laura A. Reese is professor of political science and director of the Global Urban Studies Program at Michigan State University. Her main research and teaching areas are urban politics and public policy, economic development, and local governance and management in both Canada and the United States. E-Mail: [email protected] ooking back over the body of academic work on local economic development m...

s were obtained and read for relevance to the search criteria. Articles were obtained through the internet, libraries and, in some instances, direct contact with the authors. A number of relevant publications were also obtained directly from the PHAC/NHC Secretariat. The authors and reference lists of key articles and sources obtained were analysed for appropriate reports and studies. Articles ...

multiple traveling salesman problem (mtsp) is one of the most popular operation research problem and is known as combinatorial optimization problems. mtsp is an extension version of the famous and widely used problem named traveling salesman problem (tsp). because of its benefices in various domains, many researchers have tried to solve that, and many methods have proposed so far. mtsp is a np-...

Predictors are employed to estimate the future states of a system that have many engineering applications, e.g. speech signal processors, process controllers, simulators of mechanical movements, etc. Common predictors are based on digital methods and consequently need digital processing equipment. In some cases, e.g. prediction on a real time scale and fast control, digital techniques appear ra...

Excess NaCl increases blood pressure in some strains of animals but not others. An 8% NaCl diet did not change renal thiazide receptor (TZR) density in two salt-resistant normotensive rat strains (Wistar-Kyoto and Sprague-Dawley) [Fanestil, D. D., D. A. Vaughn, and P. Blakely. Am. J. Physiol. 273 ( Regulatory Integrative Comp. Physiol.42): R1241-R1245, 1997]. However, the renal response to salt...

B iological dosimetry of ionizing radiation is generally performed by scoring dicentrics and/or translocations in chromosome from peripheral blood lymphocytes (pbl) at the first mitosis following in vitro growth stimulation. It is well known that after irradiation, in this procedure mitotic index is low in some individuals, so the scored mitoses might not be representative of the exposed cell p...

cardiovascular diseases are one of the most common diseases that cause a large number of deaths each year. coronary artery disease (cad) is the most common type of these diseases worldwide and is the main reason of heart attacks. thus early diagnosis of cad is very essential and is an important field of medical studies. many methods are used to diagnose cad so far. these methods reduce cost and...

evolutionary algorithms are some of the most crucial random approaches tosolve the problems, but sometimes generate low quality solutions. on the otherhand, learning automata are adaptive decision-making devices, operating onunknown random environments, so it seems that if evolutionary and learningautomaton based algorithms are operated simultaneously, the quality of results willincrease sharpl...

determining the optimal location of wells with the aid of an automated search algorithm is a significant and difficult step in the reservoir development process. it is a computationally intensive task due to the large number of simulation runs required. therefore,the key issue to such automatic optimization is development of algorithms that can find acceptable solutions with a minimum number of...