Linear porokeratosis is a genodermatosis, caused by a clonal proliferation of keratinocytes along the lines of Blaschko. This type of porokeratosis is particularly susceptible to malignant degeneration e.g. to Bowen disease, a squamous cell carcinoma (SCC) in situ with the potential for significant lateral spread. Here we report a case of linear porokeratosis on the left leg of a 56-year-old ma...

tological findings are different from our results. We had no evidence for other inflammatory skin diseases following Blaschko’s lines such as linear discoid lupus erythematosus or lichen striatus. Linear pigmentary disorders such as pigmentary mosaicism (naevoid hypermelanosis) or the pigmentary stage of incontinentia pigmenti were also excluded. The aetio-pathogeny of LAM remains unknown, but ...

352 groups of dilated follicular openings filled with black, hard plugs, distributed over left cheek, left arm and forearm, left side of the chest [Figure 1], abdomen, left thigh and left leg along Blaschko’s lines. The lesions over the abdomen revealed a nodulocystic swelling associated with purulent discharge [Figure 2]. The right half of the body and palms and soles over both sides were spared.

Darier disease (DD) is an autosomal-dominant skin disorder that is characterized by multiple keratotic papules, loss of epithelial adhesion, and abnormal keratinization. We describe an unusual case of late-onset unilateral segmental DD that follows the lines of Blaschko. Our patient did not exhibit other classic findings of DD. Our case and review of the literature suggest that lesions previous...

Alles, G. A. (1939). Amer. J. Physiol. 126, 420P. Blaschko, H. (1958). In 5-Hydroxytryptamine, pp. 50-57. Ed. by Lewis, G. P. London: Pergamon Press Ltd. Blaschko, H. & Himms, J. M. (1954). J. exp. Biol. 31, 1. Davison, A. N., Lessin, A. W. & Parkes, M. W. (1957). Experientia, 18, 329. Hope, D. B. (1959). Symp. biochem. Soc. 17, 93. Kobayashi, Y. (1957). Arch. Biochem. Biophy8. 71, 352. Kobayas...

Linear porokeratosis is a rare variant. It can be present at birth or can develop in adult life. Lesions of linear porokeratosis are grouped and linearly arranged along the lines of Blaschko. On the extremities it affects the distal portion more than the proximal areas. On the trunk these can be zosteriform in distribution. Lesions of linear porokeratosis probably result from an abnormal clone ...