BACKGROUND Patients with chronic kidney disease initiating an antihypertensive drug (AH) treatment must persist and comply with it to slow disease progression and benefit from the reduction of cardiovascular morbidity and mortality. OBJECTIVES This study evaluates the persistence and compliance with AH treatment and identifies the associated factors among chronic kidney disease patients who i...

aortic aneurysm is a rare but potentially lethal complication during pregnancy. in this article we described a 30-year-old woman with a large size descending aorta aneurysm (11 cm in length and 5.6 cm in its greatest diameter), who had two term uncomplicated pregnancies. the patient received prophylactic ß-blocker drug during her second pregnancy. both pregnancies were terminated by caesarean s...

mebudipine is a new dihydropyridine calcium channel blocker, synthesized in our laboratory, for treatment of hypertension. it has shown a better efficacy than other drugs in this group. for assessing the risks of this drug, certain safety tests in the preclinical stage have been performed. in this study mutagenic effect of mebudipine was evaluated using ames assay that could assess the mutageni...

Prostate cancer has been the most common malignant tumor in men Poland since 2016 and is second cause of death this group patients. The basic method treatment patients with advanced prostate androgen deprivation therapy, however, over time, evolves into a castration-resistant form, which poses significant threat to patient's life. This article presents case an elderly patient internal diseases,...

The precise mechanism by which angiotensin II type 1 receptor blocker reduces in-stent restenosis in clinical trials is unclear. We, therefore, investigated the mechanism of in-stent neointima formation. Male cynomolgus monkeys and rabbits were fed a high-cholesterol diet and were allocated to untreated control and type 1 receptor blocker groups. Five days after grouping, multilink stents were ...

Poisoning and overdose of beta-blockers may be associated with significant morbidity and mortality. Management is often complicated by failure of initial first-line interventions in severe ingestions. High-dose insulin, or hyperinsulinemia/euglycemia therapy has been well described in calcium channel blocker overdose as well as mixed ingestions of calcium channeland betablocker agents. The data...

BACKGROUND During surgical treatment of pheochromocytoma,`haemodynamic instability may occur. To prevent this, patients receive preoperative treatment with an alpha-blocker. Nowadays, some centres use phenoxybenzamine, while others use doxazosin. The purpose of this review is to analyse the current evidence of the benefits and risks of phenoxybenzamine and doxazosin in the preoperative treatmen...

OBJECTIVES This study evaluated timing of β-blocker initiation before surgery and its relationship with: 1) pre-operative heart rate and high-sensitivity C-reactive-protein (hs-CRP) levels; and 2) post-operative outcome. BACKGROUND Perioperative guidelines recommend β-blocker initiation days to weeks before surgery, on the basis of expert opinions. METHODS In 940 vascular surgery patients, ...

OBJECTIVES To perform a prospective, placebo-controlled study to examine the efficacy of alpha-blocker compared with triple therapy (alpha-blocker, anti-inflammatory, and muscle relaxant) in the treatment of Category IIIB chronic pelvic pain syndrome (Category IIIB CPPS). MATERIALS AND METHODS The study was conducted between September 2004 and December 2005, and included 90 treatment naïve pa...