BACKGROUND Testing coagulation factor activities requires that multiple dilutions be assayed and analyzed to produce a single result. The slope of the line created by plotting measured factor concentration against sample dilution is evaluated to discern the presence of inhibitors giving rise to nonparallelism. Moreover, samples producing results on initial dilution falling outside the analytic ...

Background: Coagulopathy is a common manifestation in cases of snake bite and its abnormality can be detected by blood coagulation tests. There are very few references in the literature related to coagulation parameter abnormalities after snake bite, evaluation of their seriousness and the length of the follow up period. Therefore we have undertaken this study to throw some light on the need of...

We tested the hypothesis that markers of coagulation activation are greater during lower body negative pressure (LBNP) than those obtained during blood loss (BL). We assessed coagulation using both standard clinical tests and thrombelastography (TEG) in 12 men who performed a LBNP and BL protocol in a randomized order. LBNP consisted of 5-min stages at 0, -15, -30, and -45 mmHg of suction. BL i...

BACKGROUND Excessive postoperative blood loss after cardiopulmonary bypass is a common problem, especially in patients suffering from congenital heart diseases. The efficacy of epsilon aminocaproic acid (EACA) as a prophylactic treatment for postoperative bleeding after pediatric open-heart surgery has not been determined. This meta-analysis investigates the efficacy of EACA in the minimization...

Background Traditional coagulation tests are included in emergency guidelines for management of patients on direct oral anticoagulants (DOACs) who experience acute bleeding or require surgery. We determined the ability of traditional coagulation tests and fast whole blood thromboelastography (ROTEM®) to screen for anticoagulation activity of dabigatran and rivaroxaban as low as 30 ng/mL. Meth...

In recent years a number of tests have been designed for the purpose of detection of accelerated blood coagulation. Among these are the lusteroid tube coagulation test (1-4), the silicone tube coagulation test (5), the modified clot retraction test (6), the modified Lee-White clotting test, employing three test tubes instead of one (7), the heparin retarded coagulation test of Waugh and Ruddick...

By JOHN H. FERGUSON, AARON J. MARCUS AND A. JEAN ROBINSON P LATELET PHOSPHATIDYLSERINE ( PS ) and phosphatidylethanolamine (PE) have been successfully isolated and purified1”8 by applying methods worked out by Rouser and colleagues4 for the corresponding brain phospholipids. With the modern evolution5t of clotting tests, applicable to research on the role of phosphatides7’8 in blood coagulation...

Bleeding following cardiac surgery is a serious event with potentially life-threatening consequences. Preoperative recognition of coagulation abnormalities and detection of cardiopulmonary bypass (CPB) related coagulopathy could aid in the start of preventive treatment strategies that minimize perioperative blood loss. Most algorithms that analyze thromboelastometry coagulation tests in electiv...

BACKGROUND Development of hydroxyethyl starches (HES) with a low impact on blood coagulation but a long intravascular persistence is of clinical interest. A previous in vitro study showed that low substituted high molecular weight HES does not compromise blood coagulation more than medium molecular weight HES. In the present study we assessed the individual effects on blood coagulation of molar...

abstract background assuring safety and survival of blood in vitro depends on anti-coagulation substances, blood bag characteristics, storage conditions, and transport of blood. besides, careful selection and screening of donors as well as blood tests can minimize the transmission risk of blood-transmissible pathogens and optimize blood health. the aim of this study was to assay the level of kn...