Background: Despite the requirement for increased iron delivery for erythropoiesis during hypoxia, there is very little information on how duodenal iron uptake and its transfer to the blood adapts to this condition. Aims: To assess the effects of 30 days of chronic hypoxia in rats on luminal iron uptake and transfer of the metal to blood, together with gene expression of hepcidin, a proposed ne...

Background: This study was done to highlight the magnitude of iron deficiency anemia in Bahawalpur, a big city of Southern Punjab Region of Pakistan, so that affective remedies are carried out to address iron deficiency among vulnerable groups in this part of Pakistan. There have been no such study has been conducted to assess the prevalent type of anemia in Bahawalpur region in past. Method: O...

To determine how best to assess iron status, I studied 12 young renal patients (ages 5.5 to 20 years) undergoing regular hemodialysis treatments. Iron balance was estimated by monitoring iron loss ascribable to blood loss during dialysis and diagnostic testing, and iron intake in the form of oral and intravenous iron supplements and blood transfusions. Traditional methods of evaluating iron sta...

DISCUSSION -------------------------------------------------------------------------------- Although several studies have indicated that repeated blood donation induces iron depletion and iron deficiency, all blood centers still test only hemoglobin as an indicator for selecting the donors. The present study shows the importance of measuring the iron stores and then proposed a strategy to prev...

background cardiovascular disease is the world´s leading cause of death and elevated serum iron and ferritin have been proposed as a risk factor for acute myocardial infarction (ami) in recent years. this study was done to determine the relationship between serum iron and ferritin with ami and its role on early coronary vessels disorder. material and methods in this cross-sectional study, total...

The transcellular trafficking of iron from the blood into the brain interstitium depends on iron uptake proteins in the apical membrane of brain microvascular capillary endothelial cells and efflux proteins at the basolateral, abluminal membrane. In this review, we discuss the three mechanisms by which these cells take-up iron from the blood and the sole mechanism by which they efflux this iron...

BACKGROUND Cadmium is a ubiquitous environmental pollutant associated with increased risk of leading causes of mortality and morbidity in women, including breast cancer and osteoporosis. Iron deficiency increases absorption of dietary cadmium, rendering women, who tend to have lower iron stores than men, more susceptible to cadmium uptake. We used body iron, a measure that incorporates both ser...

Background: Metals such as iron, zinc, and copper are critical and necessary for the survival of all living organisms, whereas xenobiotic metals such as lead, cadmium, mercury, and arsenic have no known biologic role. Any metals in high doses can have toxic effects. The aim of this work was to evaluate the hematological changes induced by lead as a toxic metal and characterize the potential eff...

BACKGROUND Epidemiologists have observed that blood donation is associated with decreased risk of type 2 diabetes and cardiovascular disease. METHODS We investigated the relationship between iron stores and insulin sensitivity, after controlling for known confounding factors, and compared insulin sensitivity between blood donors and individuals who had never donated blood (nondonors). In 181 ...