OBJECTIVE To evaluate whether the removal of an intraductal mass using an ultrasound (US)-guided directional vacuum-assisted device can eliminate symptoms in patients presenting with abnormal nipple discharge. MATERIALS AND METHODS Between March 2004 and October 2006, 36 patients who presented with abnormal nipple discharge, underwent US-guided, 11-gauge vacuum-assisted biopsy for a benign in...

BACKGROUND The aim of this study was to assess the diagnostic values of three breast tumor markers (i.e., CEA, CA153 and CA125) in milk and nipple discharge in the prediction of different breast diseases diagnoses. METHODS Three hundred thirty-six patients (96 breast cancer and 240 benign disease patients) with nipple discharge and a control group of 56 healthy parturient participants were en...

An expedient and cost-effective diagnostic tool is needed to complement galactography and exfoliative cytology for detection of benign or malignant breast diseases with nipple discharge. The aim of this prospective study is to explore the utility of carcinoembryonic antigen, cancer antigen 15-3 and cancer antigen 125 levels in nipple discharge for the diagnosis of various breast diseases. We ev...

INTRODUCTION Isolated single-duct nipple discharge is worrying and poses a surgical dilemma. Factors predicting malignancy are controversial. MATERIALS AND METHODS Retrospective review of 92 consecutive microdochectomies for single-duct nipple discharge in a tertiary referral centre over 8 years. RESULTS The commonest causes were ductal papilloma (52%) and fibrocystic diseases of the breast...

The distinction between breast cancer and benign breast diseases with nipple discharge remains an important diagnostic challenge. The purpose of this study was to predict the potential usefulness of tumor markers in nipple discharge and to investigate the relationship of tumor markers and clinical characteristics with breast cancer.One hundred and eleven patients with nipple discharge received ...

We reported a case of an African American woman who went to the hospital with palpable right breast lump with bloody nipple discharge at University of Texas Medical Branch at Galveston. The modalities of breast imagings included mammography and ultrasonography. The method used for viral identification was Linear Array HPV genotyping test. Intraductal papilloma revealed as high density tubular o...

A 35-year-old multipara presented at 17 weeks gestation with a right breast mass and bloody nipple discharge. On examination, she had a palpable 10 · 9 cm right breast mass and a 4 cm right axillary lymph node. A core biopsy revealed invasive ductal carcinoma. The tumor was negative for estrogen, progesterone, and HER2 receptors—a triple-negative phenotype. Limited staging with liver ultrasound...

BACKGROUND Today, in cases of nipple discharge of unclear origin, the abundance of diagnostic procedures - a, diagnostic dilemma' - becomes apparent, because unequivocal indications and a current, standardized examination sequence are presently not available. The diagnostic workup of patients with nipple discharge usually includes the clinical history, physical examination, mammography, ultraso...

nipple discharge (nd) can be the earliest presenting symptom of breast cancer. we hereby present two cases of breast cancer with no palpable mass manifesting as isolated nd, which was whitish in color. in both cases, cytology of the discharge revealed highly pleomorphic cells indicating a high grade malignancy. mammography showed diffuse, extensive microcalcifications. simple mastectomy with ax...

Breast cancer is the second leading cause of cancer death in women. Serum biomarkers such as cancer antigen 15-3 (CA15-3), cancer antigen 125 (CA125), and carcinoembryonic antigen (CEA) can be used as diagnostic and prognostic factors and can also provide valuable information during follow-up. However, serum protein biomarkers show limited diagnostic sensitivity and specificity in stand-alone a...