INTRODUCTION  Preoperative stereotactic radiosurgery (pre-SRS) is a recent advancement in the strategy for brain metastasis (BM) management, and available data demonstrate the advantages of pre-SRS before postoperative radiation treatment, including lower rates of local toxicity, leptomeningeal progression, and a high percentage of local control. The authors presented the results of pre-SRS in ...

Introduction: Mesenchymal stem cells (MSCs) hold great promise in the field of regenerative medicine.Although originally isolated from bone marrow, MSCs have since been obtained from a variety of adult and neonatal tissues including the adipose tissue. Stemness and multipotential features of Mesenchymal Stem Cells (MSC) has been highlighted in many studies but there are many dark aspects in ex...

Background: Bone marrow mesenchymal stem cells (BM-MSCs) elicit neuroprotective effects, and their repair ability has been investigated in different experimental models. We aimed to investigate the effect of multiple i.p. BM-MSCs injections in the cuprizone model of multiple sclerosis in mice. Methods: Adult male C57BL/6 mice (n = 40) were fed a regular diet or a diet containing cuprizone (0.2%...

The paucity of animal models exhibiting full pathology of diabetic retinopathy (DR) has impeded understanding of the pathogenesis of DR and the development of therapeutic interventions. Here, we investigated whether hyperhexosemic marmosets (Callithrix jacchus) develop characteristic retinal vascular lesions including macular edema (ME), a leading cause of vision loss in DR. Marmosets maintaine...

Objective(s): Nowadays much effort is being invested in order to diagnose the mechanisms involved in neural differentiation. By clarifying this, making desired neural cells in vitro and applying them into diverse neurological disorders suffered from neural cell malfunctions could be a feasible choice. Thus, the present study assessed the capability of fetal brain extract (FBE) to induce rat bon...

The Two-Way Task: Run1: TAC-M, TS-M, and Tri-BM Run2: TAC-M, TS-M, and BoW-BM Run3: TAC-M, TS-M, NE-M, & Tri-BM, BoW-BM The Three-Way Task: Run1: TAC-M, TS-M, and Tri-BM, BoWBM Run2: TAC-M, TS-M, NE-M (partial), and Tri-BM, BoW-BM Run3: TAC-M, TS-M, NE-M, and Tri-BM, BoW-BM From Two-Way to Three-Way: If BoW-BM=YES & Tri-BM=NO then CONTRADICTION If BoW-BM=YES & Tri-BM=YES then ENTAILMENT Others ...

background: gastroesophageal reflux (ger), defined as passage of gastric contents into the esophagus, and ger disease (gerd), defined as symptoms or complications of ger, are common pediatric problems. the value of commonly used diagnostic tests for ger is examined to define the most sensitive and specific test that is the least invasive as well. materials and methods: we conducted this cross s...

chronic myeloid leukemia (cml) is a myeloproliferative disease. the cytogenetic hallmark of cml is philadelphia (ph) chromosome. this study aimed to diagnose suspected cml patients, to monitor cml patients under therapy using cytogenetic and fluorescence in situ hybridization (fish) techniques to analyze their bone marrow (bm) and peripheral blood (pb) samples, and finally to compare their obta...