Follicular thyroid carcinoma (FTC) is the second most common cancer, following papillary carcinoma. Metastasis to orbital rim from FTC very rare. We recently experienced a case of with metastasis in 74-year-old woman, who initially presented huge mass and an asymptomatic solitary lesion. The lesion was suspected be separate disease entity such as lymphoma preoperative imaging, but bone finally ...

Introduction: Involvement of the skeleton can cause an excruciating pain in two-thirds of terminal patients with a history of malignancy. Due to several limitations of other therapies, such as analgesics, bisphosphonates, chemotherapy, hormonal therapy and external beam radiotherapy; bone-seeking radiopharmaceuticals have an important role in palliation of pain from bone metastases. Although th...

: Breast cancer is one of the most common malignancy in Chinese women. Up to 80% patients with metastatic breast develop bone metastasis resulting local destruction and skeletal-related events such as pathological fracture spinal cord compression. Skeletal-related pose an enormous impact on patients' motor function quality life. Therefore, prevention treatment objectives metastasis, which often...

Background: To systematically evaluate and analyze the risk factors for breast cancer (BC) with bone metastasis (BM) provide clinical evidence supporting early prevention of BM.

BACKGROUND Breast cancer has been the subject of many recent studies because it is a significant cause of death in women. This study was performed to clarify whether solitary skeletal metastasis has clinical significance compared with multiple skeletal metastasis. PATIENTS AND METHODS Seven hundred and three patients who developed metastatic bone lesions up to September 2002 after beginning t...

BACKGROUND Bone is an uncommon site of metastasis in patients with advanced hepatocellular carcinoma (HCC). Therefore, there are few studies concerning the natural history of bone metastasis in patients with HCC. PATIENTS AND METHODS Data on clinicopathology, survival, skeletal-related events (SREs), and bone-directed therapies for 211 deceased HCC patients with evidence of bone metastasis we...

Bone is the second most frequent site of metastasis resulting from thyroid cancer. Many studies have investigated clinical features and prognostic factors of distant metastases stemming from thyroid cancer in Western countries. The purpose of this study was to review clinical characteristics of Korean patients with bone metastasis originating from thyroid cancer. Between January 1985 and August...

Bone metastasis is a frequent complication of breast cancer that is often accelerated by TGF-β signaling; however, little is known about how the TGF-β pathway is regulated during bone metastasis. Here we report that deleted in liver cancer 1 (DLC1) is an important regulator of TGF-β responses and osteolytic metastasis of breast cancer cells. In murine models, breast cancer cells lacking DLC1 ex...

Background: Metastatic carcinomas to the upper jaw region are very rare and unfortunately occur in advanced stages of malignancies. Pancoast tumor is a challenging subset of lung carcinoma commonly followed by distant metastasis. Since the metastatic lesion of our patient was very huge and unusual, we decided to report the case. Case Presentation: Our patient was a middle-aged heavy smoker mal...