نتایج جستجو برای: bone mineralization
تعداد نتایج: 314895 فیلتر نتایج به سال:
Bone is a strong and tough material composed of apatite mineral, organic matter, and water. Changes in composition and organization of these building blocks affect bone's mechanical integrity. Skeletal disorders often affect bone's mineral phase, either by variations in the collagen or directly altering mineralization. The aim of the current study was to explore the differences in the mineral o...
Achondroplasia (ACH) is a short-limbed dwarfism resulting from gain-of-function mutations in fibroblast growth factor receptor 3 (FGFR3). Previous studies have shown that ACH patients have impaired chondrogenesis, but the effects of FGFR3 on bone formation and bone remodeling at adult stages of ACH have not been fully investigated. Using micro-computed tomography and histomorphometric analyses,...
PURPOSE Periodontal ligament (PDL) cell differentiation into osteoblasts is important in bone formation. Bone formation is a complex biological process and involves several tightly regulated gene expression patterns of bone-related proteins. The expression patterns of bone related proteins are regulated in a temporal manner both in vivo and in vitro. The aim of this study was to observe the gen...
In transverse sections the areas of enamel, dentine and pulp were determined using image analysis morphometry, and the mineralization levels of enamel, dentine and alveolar bone using quantitative microradiography and a microphotometric-microdensitometric technique. There were significant differences in the ratios of dentine to pulp area, and in the enamel to total area in the incisors from dwa...
Osteocytes are the cells that reside within the bone matrix and make up 90% to 95% of the cellular component of the tissue. Until recently, they were thought to serve as little more than “space holders” in the tissue. However, significant advances have demonstrated that osteocytes are of the utmost importance in regulating the dynamic nature of bone; indeed, it may be that this is their major f...
To explore how the loss of Phex function contributes to the pathogenesis of osteomalacia, we examined the abnormalities of mineralization, Phex, and bone matrix protein expression occurring in Hyp mice in vivo and in ex vivo bone marrow cell cultures. The results in vivo show that mineralization was decreased significantly in Hyp mouse bone. Phex protein was identifiable in osteoblasts and oste...
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