Bone defects, which can be caused by factors such as trauma, tumor, or osteomyelitis, are clinically common. They lessen the weight a bone is able to bear and cause severe pain patient. Although transplantation gold standard for treating it not suitable all patients due its poor availability, risk of spreading disease, possibility requiring secondary surgery. cement filler defects fill any shap...

Synchrotron X-ray bioimaging was successfully carried out to observe bone regeneration by a novel artificial bone substitute of bioactive MegaGen Synthetic Bone (MGSB) and hyaluronate (HA) hydrogels. A biphasic calcium phosphate of MGSB was prepared by chemical precipitation method, with a porous spherical morphology. On the basis of the fact that HA plays important roles in bone regeneration a...

The regeneration of bone tissue is the main purpose of most therapies in dental medicine. For bone regeneration, calcium phosphate (CaP)-based substitute materials based on natural (allo- and xenografts) and synthetic origins (alloplastic materials) are applied for guiding the regeneration processes. The optimal bone substitute has to act as a substrate for bone ingrowth into a defect, as well ...

a functional treatment for skeletal damages in orthopedic and oral maxillofacial surgeries is required. platelet growth factors such as platelet derived growth factor (pdgf), bone morphogenic factor (bmp), transferring growth factor-β (tgf-β) and insulin-like growth factor-1 (igf-1) proceed wound healing and bone regeneration. in the present study we focused on the effect of platelet rich plasm...

Bone and dental diseases are serious public health problems. Most current clinical treatments for these diseases can produce side effects. Regeneration is a promising therapy for bone and dental diseases, yielding natural tissue recovery with few side effects. Because soft tissues inside the bone and dentin are densely populated with nerves and vessels, the study of bone and dentin regeneration...

The regeneration of bone tissue is a main purpose of most therapies in dental medicine. 19 For bone regeneration, calcium phosphate (CaP)-based substitute materials based on natural (allo20 and xenografts) and synthetic origins (alloplastic materials) are applied for guiding the regeneration 21 processes. The optimal bone substitute has to act as a substrate for bone ingrowth into a defect, 22 ...

Oxygen is critical for optimal bone regeneration. While axolotls and salamanders have retained the ability to regenerate whole limbs, mammalian regeneration is restricted to the distal tip of the digit (P3) in mice, primates, and humans. Our previous study revealed the oxygen microenvironment during regeneration is dynamic and temporally influential in building and degrading bone. Given that re...

Amputation of the digit tip within the terminal phalangeal bone of rodents, monkeys, and humans results in near-perfect regeneration of bone and surrounding tissues; however, amputations at a more proximal level fail to produce the same regenerative result. Digit regeneration is a coordinated, multifaceted process that incorporates signaling from bioactive growth factors both in the tissue matr...

background: the objective of this study was to evaluate the antiinfl ammatory, antiinfective and clinical properties of amniotic membrane (am) when used for guided tissue regeneration (gtr) in contained interdental defects. materials and methods: a total of 30 subjects participated in this study. two sites in each subject were randomly assigned into each of the following experimental groups; te...