The structure of altemicidin, a new acaricidal and antitumor agent, was determined to be (1R,2S,3aR,7aS)-4-carbamoyl-2-hydroxy-6-methyl-1-(sulfamo ylacetamido)-2,3,3a,6, 7,7a-hexahydro-6-azaindene-1-carboxylic acid by a combination of spectroscopic and X-ray crystallographic analysis of its derivatives. Altemicidin is a monoterpene alkaloid.

Now a days cancer incidences are in increasing trend and therefore instant effective therapies are needed to control these malignancies. Normally rapidly dividing cells are controlled by anti-cancer drugs, but the normal cells are also affected and pattern in which it is determines the side effects. The way in which the other cells are affected determines the side effects of the individual drug...

The incidence of non-melanoma skin cancer, consisting of basal- and squamous- cell carcinoma, continues to increase in the United States and elsewhere. Solar ultraviolet (UV) B radiation has been implicated as its main cause. This adverse effect of UVB has become a major human health concern. Therefore, development of novel strategies to reduce the occurrence of skin cancer is a highly desirabl...

Typical treatment plans for attention-deficit/hyperactivity disorder (ADHD) utilize nonpharmacological (behavioral/psychosocial) and/or pharmacological interventions. Limited accessibility to behavioral therapies and concerns over adverse effects of pharmacological treatments prompted research for alternative ADHD therapies such as natural product-derived treatments and nutritional supplements....

There is a need for new options for reducing the side effects of cancer treatment, without compromising efficacy, enabling patients to complete treatment regimens. The botanical compound LCS101 exhibits inhibitory effects on cancer cell growth, and reduces chemotherapy-induced hematological toxicities. The aim of the present study is to examine the selectivity of the effects of the compound, al...

Propolis and plant secretions from three species, most frequently mentioned as botanical sources of the bee glue in Brazil (Baccharis dracunculifolia, Araucaria angustifolia and Eucalyptus citriodora) have been investigated using GC-MS. Based on chemical evidence, B. dracunculifolia was shown to be the main propolis source in São Paulo state. The antibacterial and antifungal activities of all f...

The acaricidal effect of eleven essential oils (Sweet basil, Common juniper, Atlas cedar, Coriander, Blue gum, European silver fir, Common lavender, Lemon, Peppermint, Scots pine, Summer savory) against poultry red mite Dermanyssus gallinae was tested in vitro using the direct contact method, at three different doses: 0.2 mg/cm2, 0.4 mg/cm2 and 0.6 mg/cm2. The results of the study revealed that...

Although some alternative therapies like botanical and herbal therapies have shown promise for relieving menopause symptoms such as hot flashes, more research is needed. Eighty-five percent of the women in the United States experience hot flashes of some kind as they approach menopause and for the first year or two after their periods stop. Between 20 and 50% of women continue to have them for ...

In herbalism, botanical supplements are commonly believed to be safe remedies, however, botanical supplements and dietary ingredients interact with transport and metabolic processes, affecting drug disposition. Although a large number of studies have described that botanical supplements interfere with drug metabolism, the mode of their interaction with drug transport processes is not well descr...

Acaricidal resistance studies were carried out Department of Veterinary Parasitology in Udaipur to detect status against commonly used commercial acaricides, 1.25% Butox® (Deltamethrin) and 10% w/v DERMEEZ® (Cypermethrin) ticks collected from three villages (Vallabhnagar, Ranchorpura Kikawas) Udaipur, Rajasthan using Adult Immersion test (AIT) Larval packet (LPT). Recommended concentration acar...