OBJECTIVE To determine the effectiveness of commercially available magnetic bracelets for pain control in osteoarthritis of the hip and knee. DESIGN Randomised, placebo controlled trial with three parallel groups. SETTING Five rural general practices. PARTICIPANTS 194 men and women aged 45-80 years with osteoarthritis of the hip or knee. INTERVENTION Wearing a standard strength static b...

Cyclotides are diverse plant backbone cyclized peptides that have attracted interest as pharmaceutical scaffolds, but fundamentals of their biosynthetic origin remain elusive. Backbone cyclization is a key enzyme-mediated step of cyclotide biosynthesis and confers a measure of stability on the resultant cyclotide. Furthermore, cyclization would be desirable for engineered peptides. Here we repo...

In recent years an increasing number of miniproteins containing an amide-cyclized backbone have been discovered. The cyclotide family is the largest group of such proteins and is characterized by a circular protein backbone and six conserved cysteine residues linked by disulfide bonds in a tight core of the molecule. These form a cystine knot in which an embedded ring formed by two of the disul...

The accessibility of the nervous system of Manduca sexta to horseradish peroxidase and lanthanum during metamorphosis has been studied. In the fifth instar larva, peroxidase penetrates the thick neural lamella but does not reach the perineurium. In the first week after larval-pupal ecdysis, when the intercellular channels between hypertrophied perineurial I cells are the least tortuous, the enz...

We describe a new authentication paradigm that seeks to achieve both a desirable user experience and a high level of security. We describe a potential implementation of an identity manager in the guise of a smart bracelet. This bracelet would be equipped with a low-power processor, a Bluetooth LE transmitter, an accelerometer, and a clasp that is constructed so that opening and closing it would...

BACKGROUND Recently, emotion recognition has become a hot topic in human-computer interaction. If computers could understand human emotions, they could interact better with their users. This paper proposes a novel method to recognize human emotions (neutral, happy, and angry) using a smart bracelet with built-in accelerometer. METHODS In this study, a total of 123 participants were instructed...

The mechanisms to communicate emotions have dramatically changed in the last 10 years with social networks, where users massively communicate their emotional states by using the Internet. However, people with socialization problems have difficulty expressing their emotions verbally or interpreting the environment and providing an appropriate emotional response. In this paper, a novel solution c...

Simultaneous and proportional control of a prosthetic hand and wrist is still a challenging issue, although giant steps have lately been made in this direction. In this paper, we study the application of a novel machine learning method to the problem, with the aim to potentially improve such control. Namely we apply different kernels for tensor Gaussian process regression to data obtained from ...

The embryonic development of the specialized glial cells that form the perineurial blood-brain barrier in the locust CNS has been studied by freeze-fracture and tracer uptake. These cells migrate to form bracelet cell arrangements around the nervous tissues between day 4 to day 10 of embryonic differentiation which lasts 14 days in toto. A number of different kinds of intercellular junction for...