BACKGROUND Recent insights provide support for the treatment of cancer during pregnancy, a coincidence that poses both mother and fetus at risk. Our aim was to critically review studies on the physiologic variations during pregnancy, the most common tumor markers used in diagnosis and follow-up of gynecological cancers. METHODS We conducted a systematic review of six tumor markers during norm...

BACKGROUND The current study examined the clinical usefulness of YKL-40 in detection and prognosis of uterine cervical cancer. PATIENTS AND METHODS Serum levels of YKL-40, cancer antigen 125 (CA 125), carbohydrate antigen 19-9 (CA19-9), and squamous cell carcinoma (SCC) antigen were determined by enzyme-linked immunosorbent assay in women with benign gynecologic disease (n=24), cervical malig...

A novel flow-through immunosensing system for performing a multianalyte chemiluminescent determination in a single run was designed. A new analytical strategy of substrate zone-resolved technique was proposed. Using carcinoma antigen 125 (CA 125) and carcinoembryonic antigen (CEA) as model analytes, the capture antibodies for CA 125 and CEA were immobilized on an UltraBind aldehyde-activated me...

Serum carbohydrate antigen 125 (CA-125) is a marker of ovarian cancer and obesity that is related with an increased risk of ovarian cancer. Obesity is a key factor of metabolic syndrome. We evaluated the relationship between CA-125 concentration and metabolic syndrome. The data from subjects who had any cancer and chronic infection were excluded. The data of 12,196 healthy Korean women were ana...

A new genus and species of eutherian mammal, Acristatherium yanensis gen. et sp. nov., is described from the Early Cretaceous Jehol biota, China. The new taxon is based on a partial skull that is preserved in three dimensions from the Lujiatun bed of the Yixian Formation and dated 123.2+/-1.0 Ma. Its right upper and lower dentitions are nearly complete and it has a dental formula 4.1.5.3/3.1.5....

AIM The aim of this study was to examine the relationship between serum and saliva levels of cancer antigen (CA) 125 and compare them among healthy women and patients with treated and untreated breast cancer. METHODS AND MATERIALS CA125 levels were assayed in serum and unstimulated whole saliva of 25 normal healthy women, 24 patients with untreated breast cancer, and 23 patients with treated ...

Tuberculous peritonitis is a leading cause of mortality and morbidity particularly in the developing world. Delay in initiation of treatment distinctively increases mortality. Treatment response to anti-tuberculosis drugs is usually observed by regression of symptoms and clearance of ascites. With initiation of treatment, laboratory values including CA-125 levels generally return to normal leve...

Annual screening of asymptomatic postmenopausal women using a combination of transvaginal sonography and serum Ca-125 has been evaluated in 4 major clinical trials as a means to facilitate earlier detection of ovarian cancer. In several trials, screening has caused a decrease in stage at detection. These ovarian cancer screening trials are reviewed. The effect of screening on ovarian cancer mor...

AIM To investigate seven CA125 criteria to monitor progressive ovarian cancer among patients with stage IC-IV disease. MATERIALS & METHODS Four criteria were used to asses CA125 increments starting from concentrations ≥35 U/ml and three criteria to asses increments starting from concentrations <35 U/ml. RESULTS A total of 231 patients were allocated to CA125 monitoring. The performances of ...

OBJECTIVE : To assess the diagnostic value of maternal CA 125 in patients with first trimester pregnancy and to evaluate the prognostic significance of CA 125 versus β-hCG in early pregnancies with intact fetal heartbeat, complicated by vaginal bleeding. .