We refer to the recent publication by Nakano and co-workers in Disease Models & Mechanisms (Nakano et al., 2016). This report claims that the Helicobacter pylori vacuolating cytotoxin (VacA) is the crucial factor inducing the activation of the host cell kinase for translocated CagA, Src, via a mechanism involving the receptor phosphatase RPTP-α using the human duodenum carcinoma cell line AZ-52...

Infection with Helicobacter pylori is a major risk factor for development of gastric disease, including gastric cancer. Patients infected with H. pylori strains that express CagA are at even greater risk of gastric carcinoma. Given the importance of CagA, this report describes a new molecular mechanism by which the cagA copy number dynamically expands and contracts in H. pylori Analysis of stra...

it has been also reported that that h. pylori infection may be responsible for some endocrine disorders, such as autoimmune thyroid diseases, diabetes mellitus and primary hyperparathyroidism. h. pylori which express cytotoxin-associated gene a (caga) may be more virulent than those that do not. the aim was to evaluate the seroprevalence of anti-h. pylori igg and anti-caga  antibodies in patien...

We refer to the recent publication by Nakano and co-workers in Disease Models & Mechanisms (Nakano et al., 2016). This report claims that the Helicobacter pylori vacuolating cytotoxin (VacA) is the crucial factor inducing the activation of the host cell kinase for translocated CagA, Src, via a mechanism involving the receptor phosphatase RPTP-α using the human duodenum carcinoma cell line AZ-52...

The detection of gastric premalignant lesions, atrophic gastritis, corpus atrophic gastritis, and intestinal metaplasia, using several potential markers was examined in Costa Rica. Depending on the lesion investigated, from a total of 223 dyspeptic patients, 58 (26.0%), 31 (13.9%), or 23 (10.3%) were histologically diagnosed with atrophic gastritis, corpus atrophic gastritis, or intestinal meta...

Helicobacter pylori contributes to the development of peptic ulcers and atrophic gastritis. Furthermore, H. pylori strains carrying the cagA gene are more virulent than cagA-negative strains and are associated with the development of gastric adenocarcinoma. The cagA gene product, CagA, is translocated into gastric epithelial cells and localizes to the inner surface of the plasma membrane, in wh...

Infection with cagA-positive Helicobacter pylori is critically associated with the development of gastric cancer. The cagA-encoded CagA is delivered into gastric epithelial cells via type IV secretion, where it interacts with and thereby deregulates the pro-oncogenic phosphatase SHP2. East Asian CagA and Western CagA are two major CagA species produced by H. pylori circulating in East Asian cou...

Helicobacter pylori infection is a leading cause of ulcers and gastric cancer. We show that expression of the H. pylori virulence factor CagA in a model Drosophila melanogaster epithelium induces morphological disruptions including ectopic furrowing. We find that CagA alters the distribution and increases the levels of activated myosin regulatory light chain (MLC), a key regulator of epithelial...

BACKGROUND & AIMS Helicobacter pylori CagA-positive strain is associated with gastric adenocarcinoma. CagA is delivered into gastric epithelial cells, where it undergoes tyrosine phosphorylation at the EPIYA sites by Src family kinases (SFKs). Owing to homologous recombination within the 3'-region of the cagA gene, 4 distinct EPIYA sites, each of which is defined by surrounding sequences, are v...