Citation: Quiñones LA and Lee KS (2015) Editorial: Improving cancer chemotherapy through pharmacogenomics: a research topic. It is well known that the efficacy and safety of chemotherapeutic drugs show substantial individual and/or population variability that can be explained, to a great extent, by genetic factors in pharmacokinetics and pharmacodynamics (Quiñones et al. In the context of antic...

—Most anadromous fish undergo physiological and behavioral changes that are preparatory and adaptive for seawater entry. In anadromous salmonids, these preparatory changes are collectively known as smolting. Smolt development is regulated by environmental factors such as photoperiod and temperature and mediated by the neuroendocrine system. In this paper, we review evidence that a variety of an...

Invasive species cause large economic impacts, have complex environmental impacts (Pimentel 2011) and are now considered to be among the four major threats to biodiversity. This has been recognised by their inclusion in the Strategic Plan for Biodiversity of the Convention on Biological Diversity (Aichi Target 9; UNEP 2011). Combating invasions clearly requires a prioritisation approach, taking...

there are many reasons for decrease of the functional activity of the brain like aging of the neurons, bacterial diseases and neuro inflammations. nowadays, the effects of exercise on physical and mental health have been proven but its effects on motor functions as well as neuro inflammation is an issue that has recently been studding. neuro inflammation is a mechanism that can be caused by bac...

Casting production has environmental implications that extend beyond the foundry’s premises. By taking a life-cycle approach the impacts upstream (supply side) and downstream (customer/user side) can be identified. The benefits of a foundry’s actions to reduce an environmental impact might be leveraged to reduce impacts at other stages in the life-cycle. However, as a minor player in the supply...

Now is a historic time in the field of harmful algal bloom (HAB) science. HAB problems are growing worldwide, and society's need for understanding these phenomena is more pressing than ever. Technological advances have expanded our capabilities for observing the ocean, providing unprecedented opportunities not only for the detection of blooms, but also for the physical, chemical, and biological...

A fast-growing theoretical literature on the political economy of reform has provided a sizable collection of models that have deepened our understanding concerning how distributional conflict manifests itself in the political process and can prevent efficiency-enhancing economic reform from taking place (see e.g., Allan Drazen [2000 Ch. 10, 13] for an insightful review). Unfortunately, systema...