ness anywhere; pulse 100 ; temperature ; 103'4?; respiration 50. Continue tepid sponging, ice cap, medicine, &c. To be fed every hour. Vespere.?Pulse 100 ; temperature 103 6?; respiration 42-; tongue clear, moist; bowels open once, characteristic ; slept for a few hours ; takes her food regularly; is very thirsty. 6th.?Temperature 102 ; pulse 100?; respiration 40 ; slept from 8 p.m. to 2 a.m., ...

SIR – Taxoids are new antineoplastic drugs that inhibit depolymerisation of tubulin. With docetaxel at 100 mg/m as first line chemotherapy in untreated advanced or metastatic breast cancer patients, an overall response rate of 68% was observed. About 95% of the patients receiving docetaxel 100 mg/m have a grade 3 alopecia. To prevent docetaxelinduced alopecia, we used a cold cap on 39 patients ...

Electrical activation of myelinated (A type) and nonmyelinated (C type) baroreceptor axons (BR) in aortic depressor nerve (ADN) evoked baroreflex changes in mean arterial pressure (MAP) in chloralose-urethan-anesthetized rats. Low stimulation intensities (<3 V) activated only A-type BR electroneurograms (ENG). A-type selective stimulus trains required minimum frequencies >10 Hz to evoke reflex ...

Acrolein-mediated myelin damage is thought to be a critical mechanism leading to conduction failure following neurotrauma and neurodegenerative diseases. The exposure and activation of juxtaparanodal voltage-gated K(+) channels due to myelin damage leads to conduction block, and K(+) channel blockers have long been studied as a means for restoring axonal conduction in spinal cord injury (SCI) a...

Cranial visceral afferents innervate second-order nucleus tractus solitarius (NTS) neurons via myelinated (A-type) and unmyelinated (C-type) axons in the solitary tract (ST). A- and C-type afferents often evoke reflexes with distinct performance differences, especially with regard to their frequency-dependent properties. In horizontal brainstem slices, we used the vanilloid receptor 1 agonist c...

BACKGROUND Mean platelet volume (MPV) is a reflection of platelet size, which has been shown to correlate with platelet function and activation. The aim of this study was to evaluate whether MPV could be used for the diagnostic tool of community-acquired pneumonia (CAP) and for making the decision for hospitalization. METHODS The computerized records of children aged 1 to 18 years who were di...

Epoxide hydrolases (EC 3.3.2.3) are ubiquitous enzymes that catalyze the hydrolysis of epoxides to the corresponding vicinal diols. More than 100 epoxide hydrolases (EH) have been identified or predicted, and 3 structures are available. Although they catalyze the same chemical reaction, sequence similarity is low. To identify conserved regions, all EHs were aligned. Phylogenetic analysis identi...

We report our experimental investigations on generation, propagation, and detection of very long-lived, multiple, coherent-acoustic-phonon (CAP) picosecond transients in high-quality, ultra-thin (~53 μm) GaN single-crystal platelets. Our measurements were performed using a femtosecond two-color pump-probe spectroscopy technique, with 100-fs-wide, ultraviolet laser pump pulses used to generate t...

BACKGROUND We have previously demonstrated that angiotensin II (Ang II) levels in the interstitial fluid (ISF) space of the heart are higher than in the blood plasma and do not change after systemic infusion of Ang I. In this study, we assess the enzymatic mechanisms (chymase versus ACE) by which Ang II is generated in the ISF space of the dog heart in vivo. METHODS AND RESULTS Cardiac microd...