1 Genital Mucosal HIV and STI Research Group, Division of Medical Virology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Medical Virology Laboratory, Cape Town, South Africa, 2 Genital Mucosal HIV and STI Research Group, Department of Pathology, Division of Medical Virology, NRF-DST CAPRISA CENTRE OF EXCELENCE, University of Cape Town, Cape Town, South Africa, 3...

Caffeic acid phenethyl ester (CAPE) is a bioactive component extracted from honeybee hive propolis. Our observations indicated that CAPE treatment suppressed cell proliferation and colony formation of TW2.6 human oral squamous cell carcinoma (OSCC) cells dose-dependently. CAPE treatment decreased G1 phase cell population, increased G2/M phase cell population, and induced apoptosis in TW2.6 cell...

2015 Vol 7 No 1 South Afr J Gynaecol Oncol Elhassan MMA,1 FCRadOnc, MMedRadOnc, Radiation Oncologist Wu H-T,2 FCPathAnat, MMed, Senior Consultant Van Wijk AL,3 FFRAD(T), Senior Consultant Radiation Oncology Department, National Cancer Institute, University of Gezira, Wad Madani, Sudan Department of Anatomical Pathology, University of Cape Town, Cape Town National Health Laboratory Service, Groo...

CATHERINE PITT*, ANNA VASSALL, YOT TEERAWATTANANON, ULLA K. GRIFFITHS, LORNA GUINNESS, DAMIAN WALKER, NICOLA FOSTER and KARA HANSON Department of Global Health & Development, London School of Hygiene & Tropical Medicine, London, UK Health Intervention and Technology Assessment Program, Ministry of Health, Bangkok, Thailand The Bill & Melinda Gates Foundation, Seattle, USA Health Economics Unit,...

OBJECTIVE The aim of this study is to investigate the possible protective effects of melatonin and caffeic acid phenethyl ester (CAPE) on potassium dichromate (K2 Cr2O7)-induced nephrotoxicity and genotoxicity. METHODS A total of 40 Wistar albino rats were divided into five groups: control, K2Cr2O7(K2Cr2O715 mg/kg, one dose, i.p.), K2Cr2O7 + melatonin, K2Cr2O7 + CAPE, and K2Cr2O7 + melatonin ...

a MRC/UCT Human Genetics Research Unit, Division of Human Genetics, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa b Department of Psychiatry and Mental Health, University of Cape Town, Observatory, Cape Town, South Africa c Medical Research Council (MRC) Unit on Anxiety and Stress Disorders, Cape Town, South Africa d Progra...

PURPOSE Breast cancer is an important cause of death among women. The development of radioresistance in breast cancer leads to recurrence after radiotherapy. Caffeic acid phenethyl ester (CAPE), a polyphenolic compound of honeybee propolis, is known to have anticancer properties. In this study, we examined whether CAPE enhanced the radiation sensitivity of MDA-MB-231 (estrogen receptor-negative...

OBJECTIVE The Consensus Auditory-Perceptual Evaluation of Voice (CAPE-V) was developed.to promote a standardised approach to evaluating and documenting auditory perceptual judgments of vocal quality. This tool was originally developed in English language and its Spanish version is still inexistent. The aim of this study was to develop a Spanish adaptation of CAPE-V and to examine the reliabilit...

Caffeic acid phenethyl ester (CAPE) treatment suppressed proliferation, colony formation, and cell cycle progression in PC-3 human prostate cancer cells. CAPE decreased protein expression of cyclin D1, cyclin E, SKP2, c-Myc, Akt1, Akt2, Akt3, total Akt, mTOR, Bcl-2, Rb, as well as phosphorylation of Rb, ERK1/2, Akt, mTOR, GSK3α, GSK3β, PDK1; but increased protein expression of KLF6 and p21(Cip1...

Astrophysics, Cosmology & Gravitation and Department of Mathematics & Applied Mathematics, University of Cape Town, Cape Town 7701, South Africa; 4 Department of Physics, University of Michigan, Ann Arbor, MI 48109-1040, USA; 5 Université de Genève, Département de Physique Théorique and CAP, CH-1211 Genève 4, Switzerland; 6 African Institute for Mathematical Sciences, Cape Town 7945, South Afri...