Adoptive T-cell therapy with anti-CD19 chimeric antigen receptor (CAR)-expressing T cells is a new approach for treating advanced B-cell malignancies. To evaluate anti-CD19-CAR-transduced T cells in a murine model of adoptive T-cell therapy, we developed a CAR that specifically recognized murine CD19. We used T cells that were retrovirally transduced with this CAR to treat mice bearing a syngen...

We propose and study a one-dimensional traffic flow cellular automaton (CA) model of high speed vehicles with rapid acceleration as in Fukui-Ishibashi (FI) model and with stochastic delay as in Nagel-Schreckenberg (NS) model. This model is different from the NS model in that only the cars following the trail of the ahead car can be delayed. In other words, a car with spacing ahead longer than t...

A spatial process observed over a lattice or a set of irregular regions is usually modeled using a conditionally autoregressive (CAR) model. The neighborhoods within a CAR model are generally formed using only the inter-distances between the regions. To accommodate the effect of directions, a new class of spatial models is developed using different weights given to neighbors in different direct...

Traffic simulation is an often used tool in the study of traffic systems. A traffic simulation model consists of several sub-models; each handles one specific task in the simulation. These sub-models include, among others, car-following. This model controls the interactions with the preceding vehicle in the same lane. This paper compares and describes the car-following models used in the four t...

Drawing on a data set containing 371,082 observations on new and used cars from 2008, this study employs a hedonic model to estimate the determinants of prices in the primary and secondary car markets in Germany. We are specifi cally interested in identifying those vehicle attributes that are responsible for retaining the car’s value in the used car market. Beyond parameterizing the infl uence ...