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BACKGROUND Multidrug resistant Pseudomonas aeruginosa and Acinetobacter baumannii are common causes of health care associated infections worldwide. Carbapenems are effective against infections caused by multidrug resistant Gram-negative bacteria including Pseudomonas and Acinetobacter species. However, their use is threatened by the emergence of carbapenemase-producing strains. The aim of this ...

Thirty-one A. baumannii isolates were obtained from Shar and Burn hospitals in Sulaimani City, KRG-Iraq. Bacterial identification was confirmed by detecting both 16S rRNA blaOXA-51 genes. The detection of carbapenem resistant carried out using Kirby- Bauer, RAPDEC Carba NP combined disc assays. A high rate drug resistance observed, as 74.2% the multidrug-resistant (MDR) 38.7% extensively drug-r...

The emergence of carbapenem-resistant Pseudomonas aeruginosa in the lung of a patient with cystic fibrosis was evaluated. A single strain of P. aeruginosa persisted during a 3-year study despite antipseudomonal treatment. A stepwise decrease in carbapenem susceptibility leading to resistance was observed in the absence of carbapenem treatment. These data suggest that chronic exposure to unrelat...

UNLABELLED Colistin is increasingly used as an antibiotic of last resort for the treatment of carbapenem-resistant Gram-negative infections. The plasmid-borne colistin resistance gene mcr-1 was initially identified in animal and clinical samples from China and subsequently reported worldwide, including in the United States. Of particular concern is the spread of mcr-1 into carbapenem-resistant ...

The emergence of multidrug-resistant Gram-negative bacteria, in particular Acinetobacter baumannii and Pseudomonas aeruginosa, is a critical clinical problem worldwide. Antimicrobial peptides (AMPs) have received increasing attention due to their ability to overcome multidrug-resistant microbes. We recently reported that cysteine-functionalized alpha-helical peptides LLKKLLKKC and CLLKKLLKKC ef...

The variability of carbapenem-resistant Pseudomonas aeruginosa strains (CRPA) isolated from urine and respiratory samples in a large microbiological laboratory, serving several health care settings, and from effluents of two wastewater treatment plants (WWTP) from the same region was assessed by PFGE typing and by resistance to 10 antibiotics. During the 12-month period altogether 213 carbapene...

Carbapenem-resistant Acinetobacter baumannii (CRAB) is a gram-negative bacillus that commonly causes nosocomial infection found in Indonesia. CRAB caused by resistant to Carbapenem. Resistance occurred because bacteria cause infections easily treated with antibiotics become difficult treat due the uncontrolled use of antibiotics. A. has been against carbapenem class antibiotics; and therefore, ...

The widespread of multidrug-resistant bacteria, particularly carbapenem-resistant Enterobacterales (CRE) constitutes a major public health threat worldwide, owing to the limited therapeutic options. This review will describe and uncover Saudi experience in challenge against carbapenem resistance (CR). different prevalence carbapenemase genes detected from various bacterial species were mapped f...

This manuscript reports the clinical, microbiological, and genetic characteristics of carbapenem-resistant K. pnuemoniae isolates from pediatric patients at a tertiary-care children's hospital. Although there is an extensive body of literature describing carbapenem-resistant Klebsiella infections in adults, pediatric data are comparatively limited.