During the last decade, Gram-negative clinical isolates, including Enterobacteriaceae, Pseudomonas spp. and Acinetobacter spp. with decreased susceptibility to carbapenems, have been increasingly reported in Europe. Carbapenem resistance in Enterobacteriaceae may be related either to the association of a decrease in bacterial outer-membrane permeability with overexpression of b-lactamases posse...

Abstract We report the clonal spread and evolution of high-risk Pseudomonas aeruginosa sequence type 463 co-producing KPC-2 AFM-1 carbapenemases isolated from hospital patients in China during 2020–2022. Those strains pose a substantial public health threat surveillance stricter infection-control measures are essential to prevent further infections.

Background Resistance of Klebsiella pneumoniae to carbapenems is mainly associated with acquired carbapenem-hydrolyzing b-lactamases [1]. These b-lactamases can be metallo b-lactamases (IMP, VIM), expanded-spectrum oxacillinases (OXA-48), or Ambler class A enzymes (NMCA, IMI, SME, GES, and KPC) [1,2]. The most common class A carbapenemases in K. pneumoniae are the K. pneumoniae carbapenemases (...

Microbial drug resistance is a growing problem of global magnitude. In gram-negative pathogens, the most important resistance problems are encountered in Enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter, with increasing trends observed for all major anti-gram-negative agents (beta-lactams, fluoroquinolones and aminoglycosides). A matter of major concern is the emergence of new beta-...

Enterobacteriaceae are major pathogens in both hospital and community. Recently the number of MDR phenotypes (multi drug resistant) increased, with the emergence of XDR phenotypes (extremely drug resistant – susceptible only to colistin and tigecycline). It is extremely important to detect and correct the reporting mechanisms for resistance. Many clinical laboratories have problems detecting ex...