Accumulation of calcium in the mitochondria of rat liver parenchymal cells at 16 and 24 hours after poisoning with carbon tetrachloride is associated with an increase in amount of liver inorganic phosphate, the persistence of mitochondrial adenosine triphosphatase activity, and the formation of electron-opaque intramitochondrial masses in cells with increased calcium contents. These masses, whi...

Metabolism of carbon tetrachloride is essential for its toxic effect on intracellular components of the hepatocytes (Butler, 1961 ; Recknagel, 1967). Carbon tetrachloride decreases the biliary excretion of foreign organic compounds of high molecular weight (Barakat & Abou-El-Markarem, 1973). Whether metabolism of carbon tetrachloride is also essential for this effect, will be discussed here. Va...

Acetaminophen toxicity has become a leading cause of both accidental and intentional poisoning, and is now the most common cause of acute liver failure in the United States. Acetaminophen poisoning is thus a significant burden on the health care system and a cause of considerable morbidity and mortality. Tetrathiomolybdate is a fast acting anticopper drug developed for Wilson’s disease. However...

the ethanolic extract of ficus carica leaves was screened for hepatoprotective and antioxidant activity in hepatotoxic albino rats induced via carbon tetrachloride. the degree of protection was measured by estimating biochemical parameters such as serum glutamate oxaloacetate transaminase (sgot), serum glutamate pyruvate transaminase (sgpt), total protein (tp), total albumin (ta), alkaline phos...

protective action of ficus carica leaf ethanolic extract (obtained by maceration) was evaluated in an animal model of hepatotoxicity induced by carbon tetrachloride (ccl4). male albino mice were divided into six groups. group i was normal control group; group ii received olive oil (ccl4 solvent), groups iii-vi received ccl4. after inducing hepatic damage, group iii served as control for ccl4; a...

cirrhosis is the consequence of chronic liver disease. deleterious effects of oxidative stress on hepatocytes may be reflected in the erythrocyte membrane. naltrexone (ntx) has been shown to attenuate hepatocellular injury in fibrotic animal models. the aim of this study was to investigate the progressive effect of ccl 4 on the liver and whether the improvement of liver cirrhosis can be monitor...

Rat liver microsomal membranes contain a reduced-glutathione-dependent protein(s) that inhibits lipid peroxidation in the ascorbate/iron microsomal lipid peroxidation system. It appears to exert its protective effect by scavenging free radicals. The present work was carried out to assess the effect of this reduced-glutathione-dependent mechanism on carbon tetrachloride-induced microsomal injury...

Trihalomethanes, carbon tetrachloride, 1,1,1-trichloroethane, 1,2-dibromoethane, chlorinated benzenes, ethylbenzene, and naphthalene at concentrations commonly found in surface and groundwater were incubated under anoxic conditions to study their transformability in the presence of denitrifying bacteria. None of the aromatic compounds showed significant utilization relative to sterile controls ...

Recent studies have indicated that tree carbon accumulation in subtropical forests has been negatively affected by global change phenomena such as warming and drought. However, the long-term effect of nitrogen addition on plant carbon storage remains poorly understood in these regions. In this study, we conducted a 10-year field experiment examining the effect of experimental N addition on plan...