Carbonic anhydrases catalyze the interconversion between carbon dioxide and bicarbonate. anhydrase inhibition has therapeutic importance there are many drugs which use this mechanism. inhibitors used as diuretic, antiglaucoma, antitumor antiepileptic agents. As an alternative for synthetic chemicals with strong side effects, natural products have gained popularity in recent years. In study, Sat...

BACKGROUND Increased bone resorption and new bone information are two characteristics of ankylosing spondylitis (AS). Much evidence has shown that carbonic anhydrase inhibitors can restrain bone resorption. We had detected increased expression of carbonic anhydrase I (CA1) in synovium of patients with AS. This study aimed to evaluate the effectiveness and safety of methazolamide, an anti-carbon...

The effect of calcitonin (CT) and parathyroid hormone (PTH) on carbonic anhydrase (carbonate hydrolyase, EC 4.2.1.1.) activity was tested in human erythrocyte hemolysates and with purified carbonic anhydrases I and II. The most important effect was on carbonic anhydrase II: CT showed a 2-fold increase and PTH showed a 50% decrease of carbonic anhydrase activity. This effect was observed at low ...

PURPOSE To report the efficacy of intravitreal dexamethasone implant in a patient with retinitis pigmentosa and bilateral cystoid macular edema unresponsive to topical carbonic anhydrase inhibitors. CASE REPORT A 36-year-old man with bilateral cystoid macular edema associated with retinitis pigmentosa that was unresponsive to topical carbonic anhydrase inhibitors underwent bilateral 0.7-mg in...

1-N-Alkylated-6-sulfamoyl saccharin derivatives were prepared and assayed as carbonic anhydrase inhibitors (CAIs). During X-ray crystallographic experiments an unexpected hydrolysis of the isothiazole ring was evidenced which allowed us to prepare highly potent enzyme inhibitors with selectivity for some isoforms with medical applications.

Present understanding of gene expression in erythropoietic tissues is derived solely from studies of the globin genes. Of the three distinct carbonic anhydrase (carbonate dehydratase; carbonate hydro-lyase, EC 4.2.1.1) isozymes, carbonic anhydrase I is erythrocyte-specific and, in humans, is under developmental control. The appearance of carbonic anhydrase I in the erythrocyte late in fetal lif...

To investigate the role of carbonic anhydrase in the recovery of skeletal muscle from anoxia, pH and cell phosphates were measured by (31)P-nuclear magnetic resonance in superfused newborn rabbit myotubes and cultured mouse soleus cells (H-2K(b)-ts a58) after approximately 2-3.5 h without superfusion. In control studies, pH and phosphocreatine fell and P(i) rose during anoxia and recovered with...

OBJECTIVE To report the safe and successful use of the carbonic anhydrase inhibitor acetazolamide for treatment of patients with episodic ataxia and periodic paralysis who had been denied treatment because of a history of severe allergic reactions to antibiotic sulfonamides. DESIGN Case reports. SETTING University of Rochester Medical Center, Rochester, New York. PATIENTS A 61-year-old ma...