The development of oral squamous cell carcinoma (SCC) shows a positive correlation with the carcinogen exposure that occurs during tobacco and alcohol use. The purpose of this study was to investigate whether the naturally occurring chemopreventive agent, curcumin, modulates expression and function of carcinogenmetabolizing enzymes in human keratinocytes isolated from oral SCC tumors. Dose-resp...

SUMMARY Pregnant and nonpregnant mice received injections of 3-methylcholanthrene-' 4C by several routes and were killed after various intervals. Macroautoradiographs of whole-body sections were examined, and the radioactivity in several organs was measured. The distribution of the compound in various tissues and its clearance were elucidated from the data obtained. This carcinogen is metaboliz...

The binding of N-acetoxy-N-2-acetylaminofluorene to DNA in native and partially dehistonized chicken erythrocyte chromatin was studied. The amounts of carcinogen bound to DNA were measured, after removal of proteins with phenol, by using the absorption ratio A3os/A260 or by counting the radioactivity of 14C-labeled carcinogen. Measurements of uncovered zones of DNA in chromatin were made by com...

BACKGROUND & OBJECTIVES Our previous study showed that cow ghee relative to soybean oil had a protective effect against carcinogen induced mammary cancer in rats. The objective of this study was to elucidate its biochemical mechanism. METHODS Two groups of 21 day old rats (20 each) were fed for 44 wk diet containing cow ghee or soybean oil (10%). Five animals from each group were sacrificed a...