Within the family of endogenous gasotransmitters, nitric oxide (NO) is the smallest gaseous intercellular messenger involved in the modulation of several processes, such as blood flow and platelet aggregation control, essential to maintain vascular homeostasis. NO is produced by nitric oxide synthases (NOS) and its effects are mediated by cGMP-dependent or cGMP-independent mechanisms. Growing e...

The canonical transient receptor potential channels (TRPCs) constitute a series of nonselective cation channels with variable degrees of Ca2+ selectivity. TRPCs consist of seven mammalian members, TRPC1, TRPC2, TRPC3, TRPC4, TRPC5, TRPC6, and TRPC7, which are further divided into four subtypes, TRPC1, TRPC2, TRPC4/5, and TRPC3/6/7. These channels take charge of various essential cell functions ...

A RECENT monogram issued by the Metropolitan Life Insurance Company, New York, on "The MIortality from the Principal Cardio-vascular Renal Diseases During the Twenty-Years Period from 1911 till 1930," shows how great a factor these diseases are in influencing the death-rate. For the age period 1-24 years approximately eight per cent. of all (leaths are due to cardio-vascular renal diseases, wit...

The Cardio-vascular Tissues aimed for clinical use are submitted to the European Regulation (Directives 2004/ 23EC, 2006/17EC and 2006/86EC) to assure high level of tissue quality and security. The European Directive was transposed into the Member state legislation and Standards, specific to their needs and possibilities. The Cardio-vascular tissues are recovered in the operating theatre or ano...

The incidence of syphilitic cardio-vascular disease is small in comparison with heart disease resulting from acute rheumatism and arterio-sclerosis; and of all patients suffering from cardiac disease less than one in twenty is found to be suffering from disease due to syphilis. Autopsies on syphilitic subjects have shown the aorta to be diseased in half the cases examined and recent observation...

There is lack of data on the relative importance of various conventional risk factors for cardio vascular disease among central Indians. However, cardio vascular disease risk factors have been shown to be more pronounced among diabetes subjects. The NTproBNP has been reported to be elevated in heart failure, ventricular stretch, and pressure overload. We conducted a prospective case-control stu...

Cardiovascular diseases remain one of the major health problems worldwide. The worldwide research against cardio-vascular diseases as well as genome wide association studies were successful in indentifying the loci associated with these prominent life threatening diseases but still a substantial amount of casualty remains unexplained. Over the last decade, the thorough understanding of molecula...

Allogeneic hematopoietic stem cell transplantation is mainly indicated in bone marrow dysfunction related to blood diseases, but also in some rare diseases (adrenoleucodystrophy, mitochondrial neurogastrointestinal encephalomyopathy or MNGIE...). After decades, this treatment has proven to be efficient at the cost of numerous early and delayed side effects such as infection, graft-versus-host d...

BACKGROUND Sedentary behavior is considered an independent cause of cardio-metabolic diseases, regardless of physical activity level and obesity. Few studies have reported the association between leisure sedentary time and cardio-vascular diseases in terms of occupation. METHODS We performed a cross-sectional study using data from the Korean Community Health Survey (KCHS) for 240,086 particip...