The shippers have the requests for the accessibility and economics of logistics on the premise of cargo safety, and the cargo shipping safety is an important part of logistics safety. Thus, it is quite essential to monitor the cargo shipping safety. The data is difficult to obtain in the research for cargo shipping safety, thus it cannot cover all states of influencing factors during modeling p...

Autophagy is the major pathway for the delivery of cytoplasmic material to the vacuole or lysosome. Selective autophagy is mediated by cargo receptors, which link the cargo to the scaffold protein Atg11 and to Atg8 family proteins on the forming autophagosomal membrane. We show that the essential kinase Hrr25 activates the cargo receptor Atg19 by phosphorylation, which is required to link cargo...

Cargo crime is steadily on the rise. An industry estimate states that losses from cargo, in storage or in transit surpasses $ 3050 billion per year, globally. Law enforcement officials in the US state that $ 12 million plus worth of goods are stolen from factory floors, warehouse shelves or in transit, each year (1998). With all this and more, is the cargo transportation industry turning a deaf...

Extracellular microvesicles are membranous nano-sized cellular organelles secreted by a variety of cells under normal and pathological conditions and heterogeneous in size ranging from 30 nm to 1 μm. They carry functional microRNAs that can influence immunity and development. For a particular application of microvesicles, choice of isolation method is particularly important; however, their isol...

Air cargo parties are becoming increasingb aware of the importance of Information Technology and more and more, they are understanding the value which Information Technology could provide for the total value chain performance. However, whereas in other sectors Information Technology has scored big successes, there are no real signs of successful global cotnmuni~ systems in the air cargo communi...

The hopping model for cargo transport by molecular motors introduced in Refs. [12, 13] is extended in order to incorporate the movement of cargo-motor complexes (C-MC). Hopping processes in this context expresses the possibility for cargo to be exchanged between neighboring motors at a microtubule where the transport takes place. Jamming of motors is essential for cargos to execute long-range m...

In many cellular contexts, cargo is transported bidirectionally along microtubule bundles by dynein and kinesin-family motors. Upstream factors influence how individual cargoes are locally regulated, as well as how long-range transport is regulated at the whole-cell scale. Although the details of local, single-cargo bidirectional switching have been extensively studied, it remains to be elucida...

The quality of cargo proteins in the endoplasmic reticulum (ER) is affected by their motion during folding. To understand how the diffusion of secretory cargo proteins is regulated in the ER, we directly analyze the motion of a single cargo molecule using fluorescence imaging/fluctuation analyses. We find that the addition of two N-glycans onto the cargo dramatically alters their diffusion by t...

Ubiquitin ligases of the Nedd4 family regulate membrane protein trafficking by modifying both cargo proteins and the transport machinery with ubiquitin. Here, we investigate the role of the yeast Nedd4 homologue, Rsp5, in protein sorting into vesicles that bud into the multivesicular endosome (MVE) en route to the vacuole. A mutant lacking the Rsp5 C2 domain is unable to ubiquitinate or sort bi...