A total of 1,833 mixed-sex growing-finishing pigs (PIC, 337 × 1050; initially 58.5 ± 1.62 lb) were used in a 112-d growth trial to determine the effects adding L-Carnitine throughout entire grow-finishing period or for just last 28 d before marketing on performance and carcass characteristics. There 26 replicate pens per treatment 20 (group 1) 27 2) pen completely randomized design. three diets...

Materials and methods: Semen samples were collected from 20 normal healthy volunteers. Specimens were divided into 2 aliquots (A and B) and each diluted in Ham's F-10 media to a uniform concentration of 20X10/mL. Aliquots A, were further divided and into each L-carnitine or acetyl-L-carnitine were added in concentrations of 0, 10, and 30 μM separately. All aliquots were cryopreserved for 3 days...

background: l-carnitine has been demonstrated to confer cardiac protection against ischemia reperfusion injury in animals. this study evaluates the effects of l-carnitine administration on cardiac biomarkers after coronary artery bypass graft (cabg) surgery. methods: one hundred thirty-four patients undergoing elective cabg surgery, without a history of myocardial ischemia or previous l-carniti...

We kinetically analyzed the disposition of L-carnitine of juvenile visceral steatosis (JVS) mice compared with that of normal mice to elucidate the mechanism of the systemic L-carnitine deficiency of JVS mice. There were significant differences in the plasma concentration-time course of total radioactive carnitine (L-[H]carnitine, [acetyl-H]carnitine, and other [acyl-H]carnitines) between norma...

BACKGROUND To develop and validate a simple and reliable high performance liquid chromatographic (HPLC) method for the analysis of free L-carnitine in human seminal plasma and to investigate its clinical significance as a potentially additional means of evaluating the infertile male. METHODS After proteins in seminal plasma are precipitated with a mixture of acetonitrile and methanol (9:1; v/...

Abstract Primary carnitine deficiency (PCD) can be lethal. Carnitine is essential for the transfer of long‐chain fatty acids across inner mitochondrial membrane β‐oxidation. The reported prevalence PCD in Faroe Islands 1:300 highest world. Faroese patient cohort has been closely monitored and we now report results from a 10‐year follow‐up study 139 patients. Four patients have died natural caus...

The effects of different combinations dietary lipid, L-carnitine and L-lysine on the growth performance fatty acid profiles larval grouper Epinephalus lanceolatus were evaluated. Eight treatment diets formulated based a 2x2x2 factorial design, namely 5 14% oil mixture (3:1 fish oil/soybean oil), 0 0.5% 2.83% L-lysine. Each diet was randomly assigned to triplicate groups ten 0.08g E. larvae for ...

Mersalyl inhibited the respiration of heart mitochondria under conditions that required the transport of (-)-carnitine and acyl(-)-carnitines. The exchange of external carnitine and acylcarnitines for intramitochondrial carnitine was also inhibited by mersalyl and 1 mM mersalyl proved suitable for the inhibitor-stop assay of carnitine acylcarnitine translocase. The carnitine-carnitine and (-)-c...

background and aim: in skeletal muscle, carnitine plays an essential role in the translocation of long-chain fatty-acids into the mitochondrial matrix for subsequent beta-oxidation. despite an abundance of literature describing the basic mechanisms of action of l-carnitine metabolism, there remains some uncertainty regarding the effects of oral l-carnitine supplementation on metabolism and exer...

background: the physiologic function of carnitine, oxidation of fatty acid and lipid  metabolism, is severely affected in carnitine deficiency, secondary forms of which lead to renal tubular disorders and chronic renal failure. reduction in serum carnitine has been frequently reported in patients and experimental animals treated with antiepileptic drugs, one of which, valproic acid has consiste...