Fracture healing is a complex regenerative process. Although the histology and general mechanism of repair process are already clear and well established, much remains to be understood about the process of bone healing. The source of the cells that initiate fracture repair are unclear. It is thoght that fracture repair is initiated by mesenchymal progenitor cells (MPCs) which undergo differenti...

events that leads to bony union of the broken fragments. After a fracture, the space between the ends of broken bones is filled with hematoma rich in pluripotential mesenchymal cells and cytokines. The tissue that forms within this space usually goes through a cascade of events that include cartilage formation, ossification, and remodeling phases. The roles of growth factors,1,2 ecosanoids,3 an...

Trauma is the predominant causal factor for temporomandibular joint (TMJ) ankylosis. However, the relationship between condylar fracture and TMJ ankylosis is complicated. It is believed that post-traumatic TMJ ankylosis arises from TMJ intracapsular changes, including damaged cartilage, displaced or disrupted discs, haematoma formation and subsequent fibrosis and calcification in the joint. In ...

Rib fractures are common and almost always involve the osseous component of a rib. They are typically diagnosed on plain film. Fractures of the costal cartilage are rare and are invisible on plain film. We describe a case in which computed tomography aided in the visualisation of a displaced cartilaginous fracture. To our knowledge, computed tomography-assisted diagnosis of a displaced costal f...

BACKGROUND Although tibial plateau fracture is an uncommon injury, its regulation is challenging and there are some influencing factors, including the effects of severe bone displacement, depression and cancellous bone cartilage, and inevitable cartilage damage. And GIT1 plays an important role in bone mass and 78 osteoblast cell migration. METHODS The study used 72 C57/BL6 mice. A tibial pla...

Extracellular matrix (ECM) remodeling is important during bone development and repair. Because matrix metalloproteinase 13 (MMP13, collagenase-3) plays a role in long bone development, we have examined its role during adult skeletal repair. In this study we find that MMP13 is expressed by hypertrophic chondrocytes and osteoblasts in the fracture callus. We demonstrate that MMP13 is required for...

The regeneration of adult skeletal tissues requires the timely recruitment of skeletal progenitor cells to an injury site, the differentiation of these cells into bone or cartilage, and the re-establishment of a vascular network to maintain cell viability. Disturbances in any of these cellular events can have a detrimental effect on the process of skeletal repair. Although fracture repair has b...

Introduction: Chondrogenesis occurring in soft callus is one of the major histological processes in the healing of fractures, though the molecular and cellular events, which regulate this process, have not been fully elucidated. In the present study, using a standardized rat closed fracture model, we examined the spatial and temporal gene expression for cartilage-related proteins and extensivel...

Previous studies showed that loss of tumor necrosis factor α (TNFα) signaling delayed fracture healing by delaying chondrocyte apoptosis and cartilage resorption. Mechanistic studies showed that TNFα induced Fas expression within chondrocytes; however, the degree to which chondrocyte apoptosis is mediated by TNFα alone or dependent on the induction of Fas is unclear. This question was addressed...

To gain insight into the effect of diabetes on fracture healing, experiments were carried out focusing on chondrocyte apoptosis during the transition from cartilage to bone. Type 1 diabetes was induced in mice by multiple low-dose streptozotocin injections, and simple transverse fractures of the tibia or femur was carried out. Large-scale transcriptional profiling and gene set enrichment analys...