conclusions presence of cae in patients with cas increases its cardiovascular event rate. isolated cae is not a benign finding and mi can occur. risk factors of cae are similar to cas, but c/s is more associated with cae than cas. dm is seen in cae patients less than cas. results hypertension (htn), dyslipidemia (dlp), and male sex were matched in both groups without significant difference. cig...

Cell adhesion complexes provide platforms where cell-generated forces are transmitted to the extracellular matrix (ECM). Tyrosine phosphorylation of focal adhesion proteins is crucial for cells to communicate with the extracellular environment. However, the mechanisms that transmit actin cytoskeletal motion to the extracellular environment to drive cell migration are poorly understood. We find ...

The CRISPR-Cas systems of archaeal and bacterial adaptive immunity are classified into three types that differ by the repertoires of CRISPR-associated (cas) genes, the organization of cas operons and the structure of repeats in the CRISPR arrays. The simplest among the CRISPR-Cas systems is type II in which the endonuclease activities required for the interference with foreign deoxyribonucleic ...

background: carotid artery stenting (cas) has recently been recommended as an alternative to carotid endarterectomy (cea) by some clinicians. objective: this study was designed to evaluate the success rate and in-hospital and 30-day adverse events in our first experiences in iran for cas with protection devices, to document our results and guide further use of cas. methods: from december 2003 t...

PNEUllOTHORAX DE L'ENFANT  Presentation de 17 cas. Revue de la litterature Par: Marandian M.H., Momenzadhe A., Wali­zade G., Kabiri M., A'skari H. et Movasat M.  Durant deux ans et demi, 17 cas de pneumo­thorax ont ete observes dans le service de Pedia­trie de !'Hospital Pahlavi de l'Univm-site de Teheran:  1)9 de ces malades etaient ages de moins d'un an. Le malade le plus age atteint de pn...

Intracellular signaling was once considered primarily as a sequence of chemical reactions, and the biochemical tools for studying signaling did not accommodate the context of these reactions inside the cell. It is now appreciated that intracellular signals do not occur in amorphous slush, but in ever-changing microcosms defined by membrane composition and the cytoskeleton. Elucidating the const...

When consumed separately, whey protein (WP) is more rapidly absorbed into circulation than casein (Cas), which prompted the concept of rapid and slow dietary protein. It is unclear whether these proteins have similar metabolic fates when coingested as in milk. We determined the rate of appearance across the splanchnic bed and the rate of disappearance across the leg of phenylalanine (Phe) from ...

The CRISPR/Cas (clustered regularly interspaced short palindromic repeats/CRISPR-associated proteins) system was first identified in bacteria and archaea and can degrade exogenous substrates. It was developed as a gene editing technology in 2013. Over the subsequent years, it has received extensive attention owing to its easy manipulation, high efficiency, and wide application in gene mutation ...

Compelling evidence indicates that the CRISPR-Cas system protects prokaryotes from viruses and other potential genome invaders. This adaptive prokaryotic immune system arises from the clustered regularly interspaced short palindromic repeats (CRISPRs) found in prokaryotic genomes, which harbor short invader-derived sequences, and the CRISPR-associated (Cas) protein-coding genes. Here, we have i...

CRISPR-Cas is a genetic adaptive immune system unique to prokaryotic cells used to combat phage and plasmid threats. The host cell adapts by incorporating DNA sequences from invading phages or plasmids into its CRISPR locus as spacers. These spacers are expressed as mobile surveillance RNAs that direct CRISPR-associated (Cas) proteins to protect against subsequent attack by the same phages or p...