Case memory maintenance in a Case-Based Reasoning system is important for two main reasons: (1) to control the case memory size; (2) to reduce irrelevant and redundant instances that may produce inconsistencies in the Case-Based Reasoning system. In this paper we present two approaches based on deletion policies to the maintenance of case memories. The foundations of both approaches are the Rou...

The main goal of a Case-Based Reasoning (CBR) system is to provide criteria for evaluating the internal behavior and task efficiency of a particular system for a given initial case base and sequence of a solved problems. The choice of Case Base Maintenance (CBM) strategies is driven by the maintainer's performance goals for the system and by constraints on the system's design and the task envir...

Case base maintenance is gaining increasing recognition in research and the practical ap plications of case based reasoning CBR This intense interest is highlighted by Smyth and Keane s research on case deletion policies In their work Smyth and Keane advocated a case deletion policy whereby the cases in a case base are classi ed and deleted based on their cover age potential and adaptation powe...

The 11q terminal deletion disorder is a rare genetic disorder associated with numerous clinical features. A few case reports have been made about de novo interstitial deletion of chromosome 11q. However, due to the heterogeneity in size and position of the deletions, a clear genotype-phenotype correlation is not easily made. Here we report a case interstitial 20.5-Mb deletion at chromosome 11q1...

angiotensin i-converting enzyme (ace) gene polymorphism; genotype dd or d allele may be involved with an increased susceptibility to type 2 diabetes and diabetic nephropathy (dn). we examined the frequency of ace gene polymorphism in 170 patients (85 type 2 diabetes with nephropathy and 85 without it) in tehran, iran. dna was extracted from the white blood cells and the i/d polymorphism of the ...

Ebstein anomaly is a rare heterogeneous congenital heart defect (CHD) with largely unknown etiology. We present 6-year-old girl anomaly, atrial septum defect, hypoplastic right ventricle, and persistent left superior vena cava who has de novo intragenic ~403 kb deletion of the GDP-mannose 4,6-dehydratase (GMDS) gene. GMDS located on chromosome 6p25.3 encodes rate limiting enzyme in GDP-fucose s...

BACKGROUND 46,XY disorders of sex development (46,XY DSD) are genetically heterogeneous conditions. Recently, a few submicroscopic genomic rearrangements have been reported as novel genetic causes of 46,XY DSD. METHODOLOGY/PRINCIPAL FINDINGS To clarify the role of cryptic rearrangements in the development of 46,XY DSD, we performed array-based comparative genomic hybridization analysis for 24...

Objective Approximately 15 percent of couples are infertile. The male factor is responsible for approximately 50% of the cases. One of the main genetic factors playing a role in male infertility is Y chromosomal microdeletion within the proximal long arm of the Y chromosome (Yq11), named azoospermia factor (AZF) region. Recent studies have also demonstrated that there is a potential connection ...

A Wolf-Hirschhorn syndrome is a rare chromosomal anomaly, which results from deletion of the distal portion short arm chromosome 4 (4p-), diagnosis based on clinical picture, easily recognizable in children, confirmed by molecular cytogenetics. We report case baby with wolf-Hirschhorn revealed status epilepticus.