نتایج جستجو برای: cecal ligation and perforation
تعداد نتایج: 16836817 فیلتر نتایج به سال:
Objective(s): Sepsis can result in severe organ injury by provoking inflammatory cascades and oxidative stress. Several studies are currently underway to find a drug with anti-inflammatory effects to prevent mortality and morbidity during sepsis. The present study was undertaken to assess the effects of metformin on oxidative stress and antioxidant status in sepsis induced by the Cecal Ligation...
Tocilizumab is a monoclonal antibody against the interleukin-6 receptor. Gastrointestinal perforation has been associated with treatment. In absence of specific antiviral drugs, currently being used as treatment option in patients severe COVID-19 pneumonia. This based on implication aberrant host immune response that characterizes disease and initiates patients' lung damage. Herein we present c...
In a 45-year-old woman with epigastric discomfort for 1 year, upper gastrointestinal endoscopy and endoscopic ultrasonography (EUS) showed a hypoechoic solid mass originating from the muscularis propria of the posterior wall of the gastric fundus (●" Fig.1). EUS revealed that this 0.8×0.6cm mass was probably a gastrointestinal stromal tumor (GIST) because of its morphological characteristics; t...
DUSP3 is a small dual-specificity protein phosphatase with an unknown physiological function. We report that DUSP3 is strongly expressed in human and mouse monocytes and macrophages, and that its deficiency in mice promotes tolerance to LPS-induced endotoxin shock and to polymicrobial septic shock after cecal ligation and puncture. By using adoptive transfer experiments, we demonstrate that res...
Regulatory CD4(+)CD25(+) T cells (Tregs) suppress autoimmune and inflammatory diseases through mechanisms that are only partly understood. Previous studies suggest that Tregs can suppress bacterially triggered intestinal inflammation and respond to LPS through TLRs with enhanced suppressive activity. In this study, we have used murine cecal ligation and puncture as a model of polymicrobial seps...
The leaves of Butea monosperma (Lamk) Taub (Fabaceae) have been traditionally used as tonic. Ethanolic extract of Butea monosperma contains flavonoids, glucosides, butin, butrin, isobutrin, palastrin. The present study was undertaken to evaluate the immunomodulatory activity of Butea monosperma leaves. Ethanolic extract of Butea monosperma leaves was administered at dose of 100, 200 and 400 mg/...
Volatile anesthetics are known to have immunomodulatory effects in conditions of organ injury. A recent study in an experimental sepsis model has shown remarkably improved survival when mice were exposed to volatile anesthetics. In the present study, we show that hexafluoroisopropanol - a water-soluble primary sevoflurane metabolite - has beneficial effects on the overall survival in a murine m...
سپسیس (sepsis) پاسخ سیستمیک به عفونت حاد است که شیوع آن در حال افزایش بوده و در حال حاضر سومین عامل مرگ ناشی از عفونت محسوب می¬شود. شواهد زیادی ثابت کرده¬اند که در سپسیس استرس اکسیداتیو ایجاد می¬شود. امروزه مدل¬های حیوانی التهابی مختلفی به منظور تحقیق در زمینه سپسیس وجود دارد. در این تحقیق بدلیل تکرار پذیری و آسانتر بودن از مدل (clp (cecal ligation and puncture استفاده شده است. با استفاده از ...
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