II ED CELL APLASIA is an anemia characterized by a marked reduction in the number of marrow erythroblasts.1’2 Although cases have been reported in which the blood leukocyte or thrombocyte count was also reduced, the marrow usually has a normal cellularity, normal granulopoiesis and normal megakaryocytopoiesis.1’2 \Vhile red cell aplasia is a somewhat rare disease, only 150 cases having been rep...

Thymomas are neoplasias that begin in the thymus and develop in the anterior mediastinum. They are commonly associated with a variety of systemic and autoimmune disorders, such as pure red cell aplasia, hypogammaglobulinaemia, pancytopaenia, collagen diseases, and, most commonly, myasthenia gravis. The presence of inter-current infections, especially diarrhoea and pneumonia, in the presence of ...

BACKGROUND The purpose of this study was to assess the treatment outcome after varicocele repair in azoospermic men and to correlate this outcome with the testicular histology patterns. METHODS Medical records of 15 azoospermic men who underwent testis biopsy and microsurgical repair of clinical varicocele between July 1999 and November 2000 were reviewed. All patients had at least two semen ...

mal cells having a better capacity to protect themselves.2 In CML patients developing severe BM aplasia the normal progenitor cells compartment loses the ability to adapt and the BM reservoir is severely compromised. In our case the patient received hydroxyurea for only 4 weeks and developed severe aplasia ten months later. Therefore in our case IFNplayed a pivotal role in the development of BM...

The mechanistic interplay between pesticide exposure and development of marrow aplasia is not yet well established but there are indices that chronic pesticide exposure in some instances causes marrow aplasia like haematopoietic degenerative condition in human beings. Canonical Hedgehog (Hh) signalling has multiple roles in a wide range of developmental processes, including haematopoiesis. The ...

To define further the role of marrow T suppressor lymphocytes in the pathogenesis of the hypoproliferative anemia in all Rai clinical stages of B cell chronic lymphocytic leukemia (CLL), marrow erythroid progenitor cell (CFU-E and BFU-E) frequency, marrow T gamma lymphocyte frequency per 1,000 nucleated marrow cells, and T cell-erythroid progenitor cell interactions were examined in 30 CLL pati...