Two transplantable hamster melanomas, the M-melanoma 1 and the A-melanoma 3 of Fortner, which exhibit differing growth and metastasizing properties, have been investigated with the aid of the electron microscope. The M-melanoma 1 contains melanocytes, which are characterized by the presence of melanin granules, dendritic processes, and cytoplasmic filaments. The melanin granules may be derived ...

Dystroglycan (Dg) is a transmembrane receptor for laminin that must be expressed at the right time and place in order to be involved in notochord morphogenesis. The function of Dg was examined in Xenopus laevisembryosby knockdownofDgandoverexpressionand replacement of the endogenousDgwith amutated form of the protein. This analysis revealed thatDg is required for correct laminin assembly, for c...

BACKGROUND The moisture content of diet and the dryness of the mouth alter the volume of parotid saliva secreted in rats and it plays an important part in mastication and swallowing. Temporary or permanent liquid diet feeding provides a nutritional regime for patients in certain medical situations. The aim of the present work is to investigate the sequel of liquid diet on parotid gland in rats ...

Abstract. Several foraminifera are deposit feeders that consume organic detritus (dead particulate material with entrained bacteria). However, the role of such in benthic food web remains understudied. Foraminifera feeding on methanotrophic bacteria, which 13C-depleted, may cause negative cytoplasmic and/or calcitic δ13C values. To test whether foraminiferal diet includes methanotrophs, we perf...

The intracellular distribution and level of acid hydrolases in Ochromonas malhamensis were studied in cells grown osmotrophically in a defined medium, in a carbon-free starvation medium, and during phagotrophy in each of these media. By cytochemical techniques, little enzymic reaction product was observed in the vacuoles of osmotrophic cells grown in the defined medium. Starved cells, however, ...

Yoshinori Ohsumi from the Tokyo Institute of Technology’s Frontier Research Center, Japan, has won the 2016 Nobel Prize in Physiology or Medicine for his discoveries of the mechanisms of autophagy. Fittingly for a scientist who has maintained a high profile and consistent output since his landmark discoveries in the early 1990s, Ohsumi was in his laboratory when he got the famous phone call. “I...

The present study describes a submicroscopic surface fragmentation of erythrocytes which occurs in the ascitic fluid of rats bearing the Novikoff ascites hepatoma. The resulting fragments attach to the surface of macrophages and are phagocytized by pseudopod formation. Plasma membrane in the region of these phagocytosis vacuoles appears to condense into electron-opaque material, suggesting an a...

the aim of the present study was to investigate the effects of anabolic steroid stanozolol along with eight weeks of resistance training on structural changes in male rats' liver tissue. for this purpose, 28 male adult wistar rats (age: 12 weeks old and 228.53±7.94 g body weight) were randomly assigned to four groups: group 1: control+placebo (n=7), group 2: resistance training+placebo (n=...

Tumor cell survival relies upon adaptation to the acidic conditions of the tumor microenvironment. To investigate potential acidosis survival mechanisms, we examined the effect of low pH (6.7) on human breast carcinoma cells. Acute low pH exposure reduced proliferation rate, induced a G1 cell cycle arrest, and increased cytoplasmic vacuolization. Gene expression analysis revealed elevated level...

one marrow cells with the morphological characteristics of Gaucher cells, called pseudo Gaucher cells, have been described in several hematologic disorders, 1-4 including multiple myeloma. 5 These cells have been considered storage cells, as they do not directly belong to the proliferating cell clone. We describe the presence of atypi-cal plasma cells, morphologically resembling Gaucher cells, ...