The T cell immunoglobulin- and mucin domain-containing molecules (Tim) have been implicated in the pathogenesis of immune diseases. In this study, we used quantitative real time reverse transcription polymerase chain reaction to examine the Tim 1 mRNA expression in peripheral blood mononuclear cells from Henoch Schonlein purpura patients. The results showed that Tim1 mRNA expression was signifi...

Abstract Background Immunoglobulin G4-related disease (IgG4-RD) is characterized by increased serum IgG4 concentration and infiltration of + plasma cells in the affected organs. The present study aimed to characterize levels coinhibitory checkpoint molecule, T cell immunoglobulin mucin-containing-molecule-3 (TIM-3), its ligand, galectin-9 (Gal-9), among IgG4-related patients with IgG4-RD variou...

Inhibition of immune checkpoint proteins (checkpoints) has become a promising anti-esophageal cancer strategy. We here tested expressions of immune checkpoints in human esophageal cancers. Our results showed the expressions of many immune checkpoints, including CD28, CD27, CD137L, programmed death 1 (PD-1), T cell immunoglobulin mucin-3 (TIM-3), T cell Ig and ITIM domain (TIGIT), CD160, cytotox...

Thanks to containing tumor-related molecules, small extracellular vesicles (sEVs) are emerging as biomarkers in tumor liquid biopsy and commonly employed diagnose a specific cancer. However, pan-cancer screening method for pre-symptomatic patients is crucial achieving the early cancer detection. Herein, lipid-protein capture system on herringbone (HB) microfluidic chip (HBEV-Chips) isolate mult...

background: recent researches have demonstrated that human t-cell immunoglobulin mucin 1 (tim-1) glycoprotein plays important roles in regulation of autoimmune and allergic diseases, as well as in tumor immunity and response to viral infections. therefore,targeting tim-1 could be a potential therapeutic approach against such diseases.objectives: in this study, we aimed to express tim-1 protein ...

OBJECTIVES As T-cell immunoglobulin and mucin domain 3 (TIM-3) is an immune regulatory molecule; its blocking or stimulating could alter the pattern of immune response towards a desired condition. Based on the unique features of nanobodies, we aimed to construct an anti-TIM-3 nanobody as an appropriate tool for manipulating immune responses for future therapeutic purposes. MATERIALS AND METHO...

Dysfunction of the virus-specific T cells is a cardinal feature in chronic persistent viral infections such as one caused by hepatitis C virus (HCV). In chronic HCV infection, virus-specific dysfunctional CD8 T cells often overexpress various inhibitory receptors. Programmed cell death 1 (PD-1) was the first among these inhibitory receptors that were identified to be overexpressed in functional...