Transcription factor-induced lineage reprogramming or transdifferentiation experiments are essential for understanding the plasticity of differentiated cells. These experiments helped to define the specific role of transcription factors in conferring cell identity and played a key role in the development of the regenerative medicine field. We here investigated the acquisition of DNA methylation...

The precise control of stem cell behavior, including differentiation, transdifferentiation, and reprogramming, is fundamental for safely efficiently using human cells in regenerative medicine. Thanks to recent innovations developments the field nanomedicine, as well its integration with advanced molecular biology approaches, possibility engineering restoring functions complex tissues become rea...

Differentiation programs are aberrant in cancer cells allowing them to express differentiation markers in addition to their tissue of origin. In the present study, we demonstrate the multi-lineage differentiation potential of breast cancer cell lines to express multiple neuronal/glial lineage-specific markers as well as mammary epithelial and melanocytic-specific markers. Multilineage expressio...

Transdifferentiation has been described as a novel method for converting human fibroblasts into induced cardiomyocyte-like cells. Such an approach can produce differentiated cells to study physiology or pathophysiology, examine drug interactions or toxicities, and engineer cardiac tissues. Here we describe the transdifferentiation of human dermal fibroblasts towards the cardiac cell lineage via...

Cell therapy means treating diseases with the body's own cells. The ability to produce differentiated cell types at will offers a compelling new approach to cell therapy and therefore for the treatment and cure of a plethora of clinical conditions, including diabetes, Parkinson's disease and cardiovascular disease. Until recently, it was thought that differentiated cells could only be produced ...

Cell transdifferentiation of somatic cells directly into desirable cells has sprung up in recent years, which also has provided an alternative cell source for cell therapy in regenerative medicine, comparing with cell reprogramming. However, the conventional strategy for generating target cells through transdifferentiation was mainly based on viruses expressing exogenous transcription factors, ...

Complete retinal regeneration in adult animals occurs only in certain urodele amphibians, in which the retinal pigmented epithelial cells (RPE) undergo transdifferentiation to produce all cell types constituting the neural retina. A similar mechanism also appears to be involved in retinal regeneration in the embryonic stage of some other species, but the nature of this mechanism has not yet bee...

Prostate cancer represents the second most common diagnosed in men and fifth cause of death from worldwide. In this paper, we consider a nonlinear mathematical model exploring role neuroendocrine transdifferentiation human prostate cell dynamics. Sufficient conditions are given for both biological relevance model’s solutions existence its equilibria. By means suitable Liapunov functional global...