Cellular lipids play crucial roles in the cell, including in energy storage, the formation of cellular membranes, and in signaling and vesicular trafficking. To understand the functions and characteristics of lipids within cells, various methods to image lipids have been established. In this Commentary, we discuss the four main types of molecular probes that have significantly contributed to ou...

Nucleic acid conjugates are promising drugs for treating gene-related diseases. Conjugating specific units like lipids, cell-penetrating peptides, polymers, antibodies, and aptamers either at the 3'- or 5'-termini of a siRNA duplex molecule has resulted in plethora bioconjugates with improved stabilities bloodstream better pharmacokinetic values than unmodified siRNAs. In this sense, lipid-siRN...

Lipids comprise a wide variety of substances that share the common feature of being insoluble in water but soluble in organic solvents. Fatty acids are important building blocks of lipids and they give a diversity and chemical specificity to the complex lipids found in natural fats and oils, comparable to that given by the amino acids to proteins. Because of their special characteristics and si...

IN T RO DU C T IO N Lipids play an important role in the energy storage, cellular signaling, and pathophysiology of diseases, such as cancer, neurodegenerative diseases, infections, diabetes, etc. Advances in LC/MS have allowed lipids to be studied with greater sensitivity and specificity. This alleviates the effects of co-eluting compounds and isobaric interference, and allows low abundance li...

Lipids serve many roles in the neural system, from synaptic stabilization and signaling to DNA regulation neuroprotection. They also regulate inflammatory responses, maintain cellular membrane structure, homeostatic balance of ions molecules. An imbalance lipid subgroups is implicated progression retinal diseases, such as age-related macular degeneration (AMD), retinitis pigmentosa, diabetic re...