xiii Zusammenfassung xvii Acknowledgements xxi

In this work, we investigate mechanisms to ensure that a shared data center can operate within a power budget, while optimizing a global objective function(e.g., maximize the overall revenue earned by the provider). We present the BrownMap methodology that is able to ensure that data centers can deal both with outages that reduce the available power or with surges in workload. BrownMap uses aut...

This article describes an approach to early process development in the context of the productivity model in legacy Wyeth (i.e. to deliver two New Drug Applications per year for New Molecular Entities). As a result of the model, the cycle time from lead selection to phase I decreased and the number of compounds in early development increased. In response, Wyeth Chemical Development devised a res...

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