In this work we extend results introduced in [15]. Especially, we solve the reversibility problem for DNA codes over the non chain ring Rk,s = F42k [u1, . . . , us]/〈u 2 1 − u1, . . . , u 2 s − us〉. We define an automorphism θ over Rk,s which helps us both finding the idempotent decomposition of Rk,s and solving the reversibility problem via skew cyclic codes. Moreover, we introduce a generaliz...