نتایج جستجو برای: cerebral cortex methamphetamine neurotoxicity

تعداد نتایج: 292796  

2013
Laura E Halpin William T Gunning Bryan K Yamamoto

Methamphetamine-induced neurotoxicity has been correlated with damage to the liver but this damage has not been extensively characterized. Moreover, the mechanism by which the drug contributes to liver damage is unknown. This study characterizes the hepatocellular toxicity of methamphetamine and examines if hyperthermia contributes to this liver damage. Livers from methamphetamine-treated rats ...

2000
D. Desaiah S. L. N. Reddy S. Z. Imam S. F. Ali

Methamphetamine (METH) is a potent psychostimulant known to produce neurotoxicity. The dopaminergic pathway is particularly sensitive to METH. Recent studies showed that 7-nitroindazole (7-NI), a selective inhibitor of neuronal nitric oxide synthase (nNOS), provided protection against METH neurotoxicity both in vitro and in vivo. The present studies were conducted to determine the nNOS activity...

Journal: :Journal of pharmacological sciences 2005
Mizuho Namiki Tomohisa Mori Toshiko Sawaguchi Shinobu Ito Tadashi Suzuki

An increase in polydrug abuse is a major problem worldwide. A previous study showed that coadministration of methamphetamine and morphine induced lethality in rodents and humans. However, the underlying mechanisms by which the lethality is increased by the coadministration of methamphetamine and morphine have not been fully understood. Therefore, the present study was designed to determine the ...

Journal: :iranian journal of nuclear medicine 0
vahid reza dabbagh kakhki nuclear medicine research center, mashhad university of medical sciences, mashhad, iran fereshteh madani sani cardiac anesthesia research center, mashhad university of medical sciences, mashhad, iran bita dadpour medical toxicology research center, mashhad university of medical sciences. mashhad, iran

introduction:amphetamines are central nervous system (cns) stimulant substances and amphetamine abuse is considered a growing problem in our country. previous studies revealed destructive effects of amphetamines on metabolism, perfusion and structure of brain. the aim of current study was evaluating regional cerebral blood flow (rcbf) disturbances in methamphetamine (ma) abusers using brain per...

Journal: :Psychiatry research 2013
Ruth Salo Catherine Fassbender Michael H Buonocore Stefan Ursu

The goal of this study was to extend our previous findings of abnormal prefrontal function in methamphetamine (MA) abusers and controls and to link the imaging data to behavioral, demographic and drug use variables. We used a fast event-related functional magnetic resonance imaging (fMRI) design to examine trial-to-trial reaction time (RT) adjustments in 30 MA abusers and 30 controls. A variant...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2008
Yoshimoto Sekine Yasuomi Ouchi Genichi Sugihara Nori Takei Etsuji Yoshikawa Kazuhiko Nakamura Yasuhide Iwata Kenji J Tsuchiya Shiro Suda Katsuaki Suzuki Masayoshi Kawai Kiyokazu Takebayashi Shigeyuki Yamamoto Hideo Matsuzaki Takatoshi Ueki Norio Mori Mark S Gold Jean L Cadet

Methamphetamine is a popular addictive drug whose use is associated with multiple neuropsychiatric adverse events and toxic to the dopaminergic and serotonergic systems of the brain. Methamphetamine-induced neuropathology is associated with increased expression of microglial cells that are thought to participate in either pro-toxic or protective mechanisms in the brain. Although reactive microg...

Journal: :Archives of general psychiatry 2005
Thomas E Nordahl Ruth Salo Yutaka Natsuaki Gantt P Galloway Christy Waters Charles D Moore Shawn Kile Michael H Buonocore

BACKGROUND Abnormal patterns of metabolite levels have been detected by magnetic resonance spectroscopy in frontostriatal regions of individuals meeting DSM-IV criteria for methamphetamine dependence, but less is known about the effects of drug abstinence on metabolite levels. OBJECTIVE To assess the effects of long-term methamphetamine use and drug abstinence on brain metabolite levels. DE...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2007
Jennifer Treweek Sunmee Wee George F Koob Tobin J Dickerson Kim D Janda

Methamphetamine abuse is spreading rapidly throughout the United States and is characterized by significant health consequences. The powerfully rewarding effects of methamphetamine are attributed to multiple neuropharmacological actions such as its ability to block plasma membrane transporters of all monoamines, reduce dopamine transporter expression, and inhibit monoamine oxidase activity whil...

Journal: :Brain research 2010
Syed F Ali S C Bondy

The goal of this study was twofold: (a) to search for possible interactive effects between two common drugs of abuse, ethanol and methamphetamine. b) To inquire whether any effects of ethanol could be replicated using an equivalent amount of ethanol in the form of red wine. Adult male C57/6N mice received 2% ethanol for 8 weeks in drinking water or red wine diluted to yield the same ethanol con...

Journal: :International journal of health & medical sciences 2019

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