Previous evidence demonstrated that minocycline could ameliorate clinical severity of experimental autoimmune encephalomyelitis and exhibit several anti-inflammatory and neuroprotective activities. However, few studies have been carried out to assess its effects on the expression of neurotrophins in experimental autoimmune encephalomyelitis or multiple sclerosis. Here we investigated the altera...

To explore the role of brain-derived neurotrophic factor for survival and generation of striatal neurons after stroke, recombinant adenoassociated viral vectors carrying brain-derived neurotrophic factor or green fluorescent protein genes were injected into right rat substantia nigra 4–5 weeks prior to 30 min ipsilateral of middle cerebral artery occlusion. The brain-derived neurotrophic factor...

conclusions this study shows that bdnf and ngf expression decreases in diabetic neuropathy. however, this decrease can be reversed through endurance training. these results also indicate that endurance training may have a potential role in compensating for neurotrophin deficiency following diabetic neuropathy. objectives this experimental study was designed and carried out at the tarbiat modare...

To begin to identify novel protein(s) that acts on nigral dopaminergic (DA) neurons, we characterized trophic effects of DA-depleted striatum on survival of fetal DA neurons in the present study. Treatment of ventral mesencephalic cultures with the striatal extracts delayed DA cell death in a dose-dependent manner. This effect was partially dependent on brain-derived neurotrophic factor (BDNF),...

L-DOPA is toxic to catecholamine neurons in culture, but the toxicity is reduced by exposure to astrocytes. We tested the effect of L-DOPA on dopamine neurons using postnatal ventral midbrain neuron/cortical astrocyte cocultures in serum-free, glia-conditioned medium. L-DOPA (50 microM) protected against dopamine neuronal cell death and increased the number and branching of dopamine processes. ...

Increasing evidence indicated astroglia-derived neurotrophic factors generation might hold a promising therapy for Parkinson's disease (PD). Resveratrol, naturally present in red wine and grapes with potential benefit for health, is well known to possess a number of pharmacological activities. Besides the antineuroinflammatory properties, we hypothesized the neuroprotective potency of resveratr...

low glucose condition induces neuronal cell-death via intracellular mechanisms including mitogen-activated protein kinases (mapk) signaling pathways. it has been shown that low glucose medium decreases neuronal survival in cerebellar granule neurons (cgns). in this study, we have examined the activation of jnk, p38kinase and erk1/2 pathways in low glucose medium in cgns. the cgns were prepared ...