Aims:Memory deficit is the most visible symptom of cerebral ischemia. The hippocampus is sensitive against cerebral ischemia. Oxidative stress and inflammation are involved in the pathological process after cerebral ischemic injury. Paroxetine has anti-oxidative and anti-inflammatory effects. In this study the effect of paroxetine on memory deficit after cerebral ischemia was investigated. Meth...

Background: Cerebral ischemic reperfusion injury (CI/RI) is a common cerebrovascular disease with high morbidity and disability that threatens human health. This study was conducted to explore the effects of dexmedetomidine (Dex) on c-Jun N-terminal kinase (JNK) pathway in CI/RI, provide theoretical basis for recovery brain function after cerebral ischemia.

BACKGROUND AND PURPOSE Hypocapnic cerebral vasoconstriction is used therapeutically to reduce elevated intracranial pressure caused by cerebral edema. Because cerebral ischemia/reperfusion injury causes a selective loss of prostanoid-dependent responses, including vasodilation to hypercapnia, we designed these experiments to examine the effect of ischemia/reperfusion on hypocapnic cerebral vaso...

Lipoxin A4 can alleviate cerebral ischemia/reperfusion injury by reducing the inflammatory reaction, but it is currently unclear whether it has a protective effect on diabetes mellitus complicated by focal cerebral ischemia/reperfusion injury. In this study, we established rat models of diabetes mellitus using an intraperitoneal injection of streptozotocin. We then induced focal cerebral ischem...

INTRODUCTION Cerebral ischemia and reperfusion causes physiological and biochemical changes in the neuronal cells that will eventually lead to cell damage. Evidence indicates that exercise reduces the ischemia and reperfusion-induced brain damages in animal models of stroke. In the present study, the effect of exercise preconditioning on brain edema and neurological movement disorders following...

introduction: several studies have indicated that late treatment of aminoguanidine (ag) reduces cerebral ischemic injuries in animal models. however, the effects of early treatment of ag on cerebral ischemic damage are not well understood. this study was designed to evaluate effect of early treatment of ag on cortex and striatum injuries as well as neurological dysfunctions in transient model o...

Pervious studies have shown that pentoxifylline (PTX) has beneficial effects in reduction of stroke and brain trauma injuries in experimental animals. However, there is very little and controversial information about the effect of PTX on brain edema in cerebral ischemia. Therefore, the aim of this study was to determine the effects of different doses of PTX on brain edema and neurological m...

background: nepeta dschuparensis bornm (np) is used as a medicinal herb in iran. in traditional medicine, this herb is extensively employed for curing ailments such as cardiovascular diseases. np has antioxidant and anti-inflammatory properties. this project examined the effects of the np extract on cyclooxygenase-2 (cox-2) and interleukin-1β (il-1β) protein levels and its efficacy in neuroprot...

Abstract Cerebral ischemia is an extremely complex disease that can be caused by a variety of factors. cause great harm to human body. Sevoflurane volatile anesthetic frequently used in clinic, and has lot advantages, such as quick induction general anesthesia, anesthesia recovery, no respiratory tract irritation, muscle relaxation, small cycle effect. The mechanism sevoflurane preconditioning ...

Aims:Memory deficit is the most visible symptom of cerebral ischemia. The hippocampus is sensitive against cerebral ischemia. Oxidative stress and inflammation are involved in the pathological process after cerebral ischemic injury. Paroxetine has anti-oxidative and anti-inflammatory effects. In this study the effect of paroxetine on memory deficit after cerebral ischemia was investigated. Meth...