BACKGROUND AND PURPOSE Previous pathological studies in humans or in animal models have shown alterations of small arteries and veins within white matter lesions in cerebral small vessel disease. We aimed to evaluate in vivo, the integrity of the cerebral venous network using high-resolution MRI both within and outside white matter hyperintensities in cerebral autosomal-dominant arteriopathy wi...

A Method for Measuring Cerebral Hemispheric Blood Flow and Metabolism • A new method for measuring cerebral hemispheric blood flow together with metabolism using an injection of a 5 ml bolus of hydrogen-saturated saline into each internal carotid artery is described. This method was extensively evaluated in the monkey prior to being used in man. Under fluoroscopic control, a catheter was insert...

Chronic cerebrospinal venous insufficiency (CCSVI) has been described as a venous condition with abnormal flow in extracranial and intracranial veins. CCSVI, as evaluated by ultrasound, has been hypothesized to be associated with multiple sclerosis (MS), possibly even causing MS. Five venous characteristics (often referred to as criteria) were recommended to evaluate CCSVI: criterion 1 evaluate...

The possible causes of postoperative brain damage were examined in 100 cases of cerebral aneurysms operated on by the pterional approach. Postoperative brain damage occurred in 15% of cases, located mostly in the inferior frontal lobe. Its incidence was higher in early than in delayed operation and increased with severity of preoperative clinical conditions but not correlated with patient age a...

OBJECTIVE To investigate recanalisation in the first 12 months after cerebral venous thrombosis. METHODS 33 consecutive patients presenting with cerebral venous thrombosis were enrolled in the study. Diagnosis was made by magnetic resonance imaging (MRI) and magnetic resonance venography (MRV) or catheter angiography. Patients were initially treated with intravenous heparin. Warfarin was give...

Understanding amazingly complex brain functions and pathologies requires a complete cerebral vascular atlas in stereotaxic coordinates. Making a precise atlas for cerebral arteries and veins has been a century-old objective in neuroscience and neuropathology. Using micro-optical sectioning tomography (MOST) with a modified Nissl staining method, we acquired five mouse brain data sets containing...

BACKGROUND AND PURPOSE Outcome from sinus vein thrombosis is very variable, with symptoms from headache to coma. Experimental findings suggest that an involvement of cortical veins is necessary to affect the cerebral microcirculation. Laser Doppler flowmetry was used to investigate the regional and temporal changes in local cortical blood flow after experimental occlusion and thrombosis of the ...

Immunohistochemistry and autoradiography were used to identify sites of the cytochrome P450 enzymes (P450) 1A1 and 1B1 expression and activation of 7,12-dimethylbenz(a)anthracene (DMBA), in the brain of rodents pretreated with the aryl hydrocarbon receptor (AhR) agonists beta-naphthoflavone (BNF), 3,3',4,4',5-pentachlorobiphenyl or vehicle. Immunohistochemistry revealed that CYP1A1 was preferen...

PURPOSE To report the anatomic and radiologic development of the transverse, sigmoid, and occipital sinuses, the emissary veins, and the jugular bulb formation from the jugular sinus in humans before and after birth. METHODS Roentgenograms of 33 injected brains showing the cranial venous system in human fetuses from 3 to 7 months of gestational age and cerebral angiograms of newborns and infa...

A 20 year-old Turkish patient presented with superlor sagittal and lateral sinus thrombosis, The frequency of cerebral venous thrombosis generally is understimated and rnay be the first clinical manifestation. In case of intracranlal hypertension, cerebral venous thrombosis and Behgetbs disease should be tal[en into consideration, especially in the high risk population from Eastern Mediterranea...