The cyclic peptide Melanin Concentrating Hormone (MCH) is known to control a large number of brain functions in mammals such as food intake and metabolism, stress response, anxiety, sleep/wake cycle, memory, and reward. Based on neuro-anatomical and electrophysiological studies these functions were attributed to neuronal circuits expressing MCHR1, the single MCH receptor in rodents. In compleme...

PYOGENIC meningitis is defined by the presence of polymorphonuclear leucocytes ('pus cells') in cerebro-spinal fluid (CSF). This virtually excludes infection with viruses, rickettsiae, fungi, and, except in the acute stages, with the tubercle bacillus. Although the mortality and morbidity of this condition have decreased considerably since the introduction of chemotherapy, it still remains regr...

This work presents an automatic brain MRI segmentation method which can classify brain voxels into one of three main tissue types: gray matter (GM), white matter (WM) and Cerebro-spinal fluid (CSF). Intensity-model based classification of MR images has proven problematic. The statistical approach does not carry any spatial, textural and neighborhood information in it. We propose to use a comput...

The following four cases of meningitis and cerebro-spinal ralmingitis occurred in the Akyab jail during the months of November and December last. The origin of the disease was very obscure since all "the patients had been inmates of the jail for some long period previous to being attacked, and according to the registers no cases of this latter disease have ever occurred either in the Akyab jail...

Scire est nescire, nisi id me Scire alius sciret SUMMER, 1940.

and in the Rhine coal districts. He points out that school epidemics are unknown ; that second cases in the same house are uncommon ; that cases of cerebro-spinal meningitis which have been put into scarlatina or other wards on a wrong diagnosis do not give rise to further cases in these wards ; and that meningococci are not found in the noses of the other children in these wards. He concludes ...

Tuberculous meningitis (TM) is the deadliest form of tuberculosis. Nearly two-thirds of HIV infected patients with TM die, and most deaths occur within one month. Current treatment of TM involves the use of drugs with poor penetration into the cerebro-spinal fluid (CSF). In this study, we present the mortality before and after implementing a new antituberculous regimen (ATR) with a higher drug ...

Tuberculous Meningitis (TBM) is one of the leading causes of deaths and disabilities in the developing nations like India. Rapid diagnosis of the cases is essential to minimise the mortality and morbidity. Although clinical diagnosis is made based on the presenting symptoms, signs and radiological imaging studies, confirmation of the diagnosis is still difficult and there are significant diagno...