mumps infection is endemic in iran. our objective was to evaluate the presence of anti mumps antibodies ( igm & igg) in cerebrospinal fluid in mumps meningoencephalitic children. a prospective/cross-sectional study was performed in tehran, iran (2003 to 2004) and serum anti mumps antibodies (igm) were detected (quantitive; elisa) in meningoencephaltis patients. specific anti mumps antibodies (i...

objective cerebrospinal fluid (csf), its secretion, circulation and absorption have been the subject of recent researches. there is a general agreement that the main site of csf secretion is in the choroids plexus. however, the main absorption site is controversial. some believe that arachnoid granulations are the principle sites of csf absorption. in this study, different locations of csf abso...

Pneumocephalus is a well-known condition following head trauma, but is rare as an injury or as a result of surgery of the spine. We present a 76-year-old patient with a rare case of pneumocephalus associated with a cerebrospinal fluid fistula as a complication of surgical treatment for cervical myelopathy. Although cerebrospinal fluid leakage was noted and the injured dura was carefully sutured...

Fibrin/fibrinogen degradation products (fragments D and E) were detected in cerebrospinal fluid in 23.4% of 252 patients admitted to a neurological/neurosurgical unit. Other coagulation proteins of low molecular weight (plasminogen and factor IX) were also present but larger proteins (fibrinogen and factor V) were not. These findings are consistent with protein leakage across a blood-CSF barrie...

Uncontrolled cerebrospinal fluid (CSF) leakage after transsphenoidal surgery (TSS) for pituitary adenoma can lead to meningitis. Intracranial mycotic pseudoaneurysm is a rare complication in central nervous system infection. Large single pseudoaneurysm is more uncommon. Most mycotic aneurysms occur due to endocarditis. The present patient had no heart problem and was infected by CSF leakage aft...

Intracranial hypotension is typically manifested by orthostatic headache. The most frequent underlying factor is cerebrospinal fluid leakage. It has been suggested that dural structural weakness in some connective tissue diseases may be responsible for dural tears and diverticula and consequently leakage. We present a case of spontaneous intracranial hypotension associated with Marfan syndrome ...

To clarify the significance of immunoglobulin G autoantibody specific for the astrocyte water channel aquaporin-4 in cerebrospinal fluid, aquaporin-4-immunoglobulin G from a neuromyelitis optica patient was administered intrathecally to naïve mice, and the distribution and pathogenic impact was evaluated. A distinct distribution pattern of aquaporin-4-immunoglobulin G deposition was observed in...

Chronic serous otitis media is a common problem in the daily routine of the otorhinolaryngologist. In the majority of cases, the cause is related to dysfunction of the eustachian tube due to viral or bacterial rhinitis and occasionally to nasopharyngeal tumors. We report a case of a patient presenting with chronic serous otitis media that was resistant to conventional therapy. MRI with gadolini...

A patient with spontaneous intracranial hypotension due to a spinal cerebrospinal fluid (CSF) leak required localization of the leakage site prior to surgical management. Conventional, computed tomography and prone digital subtraction myelography failed to localize the dural tear, which was postulated to be dorsally located. We present here a digital subtraction myelographic approach to accurat...

CSF fistula/CSF leak is a pathological disorder that spans all ages. the primary clinical characteristic of this disorder is abnormal leakage of cerebrospinal fluid (CSF), from CSF containing compartments of the central nervous system (CNS) to the around space due to abnormal defect of the Dura matter and the skull [1], which typically appears as a clear watery leakage from nose (rhinorrhea) or...