The aetiology of Schizophrenia is still obscure. This case report is of interest because it draws attention to a hitherto neglected area in this filed, i.e., the role of cerebro-vascular malformation and the resulting insufficiency in the cerebral circulation as a possible factor in the pathogenesis of Schizophrenia.

Modern views of stroke prevention are discussed. Novel and traditional concepts of pathogenesis of acute disorders of cerebral circulation are summarized for the first time, methods for individual prognostication of vascular events are proposed. Universally recognized strategies of stroke prophylaxis are analysed and new approaches to differential preventive treatment depending on the probabili...

Ischemic cerebrovascular disease, a major public health problem, is accompanied, and possibly caused in a large percentage of cases, by extracranial arterial lesions. A rapidly expanding body of surgical litera­ ture records the success of procedures designed to re­ pair these lesions along with a decline in recent years in surgical mortality for such procedures. If an area of carotid abnormali...

RATIONALE Cerebrovascular regulation is impaired in patients with moderate to severe obstructive sleep apnea; however, it is unknown whether this impairment exists in individuals with less severe sleep-disordered breathing. OBJECTIVES To test the hypothesis that cerebrovascular responses to hypercapnia are attenuated in a nonclinical population-based cohort. METHODS A rebreathing test that ...

Recent evidence indicates that elevated plasma levels of homocysteine are a risk factor for ischemic cerebrovascular diseases. However, little is known about cerebrovascular effects of homocysteine. Homocysteine could impair cerebrovascular function by metal-catalyzed production of activated oxygen species. We studied whether homocysteine, in the presence of Cu2+, alters reactivity of cerebral ...

Obstructive sleep apnea, a condition resulting in chronic intermittent hypoxia (CIH), is an independent risk factor for stroke and dementia, but the mechanisms of the effect are unknown. We tested the hypothesis that CIH increases cerebrovascular risk by altering critical mechanisms regulating cerebral blood flow thereby lowering cerebrovascular reserves. Male C57Bl6/J mice were subjected to CI...

A recent experiment measured responses to dissonance. Dissonance can consistently create feelings of unpleasantness in a subject, even if the subject has never heard the music before. Music of varying dissonance was played for the subjects, while their cerebral blood flow was measured. Increased blood flow in a specific area of the brain corresponded with increased activity. It was found that t...

Laser-speckle flowmetry was used to characterize activation flow coupling after electrical somatosensory stimulation of forepaw and hindpaw in the rat. Quantification of functional activation was made with high transverse spatial (microm) and temporal (msec) resolution. Different activation levels and duration of stimulation were quantitatively investigated, and were in good agreement with prev...