Abstract Background Inhibition of nuclear import via Karyopherin beta 1 (Kpnβ1) shows potential as an anti-cancer approach. This study investigated the use inhibitor, INI-43, in combination with cisplatin. Methods Cervical cancer cells were pre-treated INI-43 before treatment cisplatin, and MTT cell viability apoptosis assays performed. Activity localisation p53 NFκB was determined after co-tre...

Tafazzin (TAZ) is often aberrantly expressed in some cancers, including rectal cancer and thyroid neoplasms. However, the function of TAZ in cervical cancer cells remains unknown. This study aims to explore the expression and function of TAZ in cervical cancer cells. Here, we determined the expression of TAZ protein in normal cervical tissue (NC, n = 27), high-grade squamous intraepithelial les...

MicroRNAs (miRNAs) are a cluster of short non-coding RNAs playing critical roles in human cancers. miR-187 was recently found to be a novel cancer-related microRNA. However, the expression and function of miR-187 in cervical cancer have not been investigated. In this study, we found that miR-187 level was decreased in cervical cancer tissues and cell lines. Patients with low level of miR-187 ha...

Cervical cancer is screened by pap smear methodology for detection and classification purposes. Pap images of the cervical region are employed to detect classify abnormality tissues. In this paper, we proposed first system that it ables into a seven classes problem. exploited design computer-aided diagnoses in cells. Automated features have been extracted using ResNet101 discriminate Support Ve...

miRNA-203 is involved in the development and progression of various types of cancer. However, its role in cervical cancer remains unclear. The aim of this study was to investigate the effect of miRNA-203 on the proliferation and migration of HeLa cervical cancer cells, as well as survivin expression in these cells. A miRNA-203 primer probe was designed according to a sequence obtained from NCBI...

background: cervical cancer is the third most common cancer in women in the world. papanicolaou smear is known as a standard test for cervical cancer screening; however, the most important challenge is high rates of false negative results. the aim of this study was to compare the quality of smears obtained by anatomical spatula and spatula-cytobrush. the most important factor in false negative ...

conclusions adc valuecould be a prognostic factor to monitor the response to therapy for patients with cervical cancer. the addition of dw-mri to the conventional mri protocolsconsiderably improved the diagnostic ability of mr imaging method for tumor evaluations. results studies had shown thatthe mean adc value of cervical carcinoma (1.110 ± 0.175 × 10-3 mm2/s)is significantly lower than that ...

OBJECTIVE This study aimed to evaluate the relationship between forkhead box P3 (Foxp3) expression and clinicopathological characteristics of cervical cancer and to explore the influence of Foxp3 on the biological behaviors of cervical cancer cells. METHODS In this study, immunohistochemistry, lentivirus mediated transfection, Transwell assay; CCK-8 assay, real-time PCR and flow cytometry wer...